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上海药物研究所 [22]
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期刊论文 [37]
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2021 [37]
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Chemistry [1]
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Ropivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis
期刊论文
BIOENGINEERED, 2021, 卷号: 12
作者:
Zhang, Runze
;
Lian, Yanhong
;
Xie, Kangjie
;
Cai, Yunfang
;
Pan, Yafei
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/01/10
Ropivacaine
hepatocellular carcinoma
IGF-1R
IGF1R-PI3K-AKT-mTOR signaling
cell cycle
epithelial-mesenchymal transition
DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:
Shu, Yuhan
;
Sun, Xin
;
Ye, Guiqin
;
Xu, Mengting
;
Wu, Zhipan
收藏
  |  
浏览/下载:156/0
  |  
提交时间:2022/02/14
DHOK
transcriptome sequencing
autophagy
colorectal cancer
mTOR pathway
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
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  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Li, Qinglin
;
Xia, Liang
;
Sun, Caixing
;
Zhang, Huangjie
;
Zheng, Mengying
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  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
natural product
borneol
malignant glioma
autophagy
HIF-1 alpha
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12
作者:
Wang, Lan
;
Zhao, Danfeng
;
Wang, Huan
;
Wang, Lele
;
Liu, Xiaohui
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  |  
浏览/下载:62/0
  |  
提交时间:2021/12/01
Inflammation
Microglia
LPS
RNA-seq
JAK
STAT signaling pathway
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway
期刊论文
MATERIALS TODAY BIO, 2021, 卷号: 12, 页码: 13
作者:
Wei, X.
;
Tang, Z.
;
Wu, H.
;
Zuo, X.
;
Dong, H.
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/12/09
Magnesium
Coating
Antitumour
Autophagy
Apoptosis
MD2 blockage prevents the migration and invasion of hepatocellular carcinoma cells via inhibition of the EGFR signaling pathway
期刊论文
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2021
作者:
Qi, Yajun
;
Fang, Qilu
;
Li, Qinglin
;
Ding, Haiying
;
Shu, Qi
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/09/06
Hepatocellular carcinoma (HCC)
myeloid differentiation protein 2 (MD2)
epidermal growth factor receptor (EGFR)
migration
invasion
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