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上海药物研究所 [17]
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合肥物质科学研究院 [4]
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期刊论文 [29]
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2021 [29]
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A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
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浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
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  |  
浏览/下载:53/0
  |  
提交时间:2022/03/21
Efficacy and Safety of Recombinant Human-Mouse Chimeric Anti-CD20 Monoclonal Antibody (SCT400) Combined with CHOP in Patients with Treatment-Naive Diffuse Large B-Cell Lymphoma: A Multicenter, Randomized, Single-Blind, Parallel Active-Controlled, Phase III Study
期刊论文
BLOOD, 2021, 卷号: 138
作者:
Shi, Yuankai
;
Zhang, Qing Yuan
;
Hong, Xiaonan
;
Wang, Zhen
;
Gao, Yuhuan
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  |  
浏览/下载:15/0
  |  
提交时间:2022/12/23
Impurity Identification and Scale-Up of a Novel Glycopeptide Antibiotic
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2390-2402
作者:
Jiao, Shang
;
Guan, Dongliang
;
Xu, Lili
;
Liu, Bo
;
Shi, Weiwei
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  |  
浏览/下载:19/0
  |  
提交时间:2022/01/18
glycopeptide antibiotics
impurity
analytical method
process optimization and development
Cross-identification of N-Glycans by CE-LIF using two capillary coatings and three labeling dyes
期刊论文
Talanta, 2021, 卷号: 239, 页码: 10
作者:
PingjingLi
;
LuluWang
;
RuiGuo
;
HuataoFeng
;
YaJi
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  |  
浏览/下载:1/0
  |  
提交时间:2021/11/17
Capillary coating
Capillary electrophoresis-laser induced fluorescence
Fluorogenic dyes
Immunoglobulin G
N-Glycans
An enhanced strategy integrating offline two-dimensional separation with data independent acquisition mode and deconvolution: Characterization of metabolites of Uncaria rhynchophylla in rat plasma as a case
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 8
作者:
Li, Haojv
;
Wei, Wenlong
;
Li, Zhenwei
;
Wang, Mengyuan
;
Wei, Xuemei
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  |  
浏览/下载:51/0
  |  
提交时间:2021/11/04
Off-line 2D separation system
Metabolites characterization in vivo
Data independent acquisition
Multi-dimensional deconvolution
Uncaria rhynchophylla
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 9
作者:
Chen, Yuning
;
Zhang, Ya-Nan
;
Yan, Renhong
;
Wang, Guifeng
;
Zhang, Yuanyuan
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  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
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  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
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  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Treatment efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization versus regorafenib monotherapy in colorectal cancer liver metastasis patients who fail standard treatment regimens
期刊论文
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021
作者:
Cao, Fei
;
Zheng, Jiaping
;
Luo, Jun
;
Zhang, Zhewei
;
Shao, Guoliang
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  |  
浏览/下载:47/0
  |  
提交时间:2021/08/30
Regorafenib plus DEB-TACE
CRLM
Treatment response
Prognosis
Adverse events
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