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上海药物研究所 [11]
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期刊论文 [49]
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2021 [50]
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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12
作者:
Zhou, Jiashen
;
Zhang, Lin
;
Zeng, Liping
;
Yu, Lu
;
Duan, Yuanyuan
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  |  
浏览/下载:85/0
  |  
提交时间:2022/01/10
Laser-assisted high-performance PtRu alloy for pH-universal hydrogen evolution
期刊论文
ENERGY & ENVIRONMENTAL SCIENCE, 2021
作者:
Pang, Beibei
;
Liu, Xiaokang
;
Liu, Tianyang
;
Chen, Tao
;
Shen, Xinyi
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/10
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
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  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella
期刊论文
RSC MEDICINAL CHEMISTRY, 2021, 页码: 12
作者:
Guan, Xiang-Na
;
Zhang, Tao
;
Yang, Teng
;
Dong, Ze
;
Yang, Song
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  |  
浏览/下载:20/0
  |  
提交时间:2021/12/16
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
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  |  
浏览/下载:84/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
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  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Ultrathin, Porous CoPS Nanosheets: GO Self-Sacrificing Template Synthesis as Bifunctional Catalysts for Overall Water Splitting
期刊论文
ACS APPLIED ENERGY MATERIALS, 2021, 卷号: 4, 期号: 10, 页码: 10976-10985
作者:
Zhao, Wenhua
;
Wu, Niandu
;
Yu, Fan
;
Zhou, Boye
;
Chu, Xueyuan
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  |  
浏览/下载:16/0
  |  
提交时间:2021/12/17
overall water splitting
bifunctional electrocatalyst
CoPS nanosheets
graphene oxide
sacrificial template
Structural insights into the activation of human calcium-sensing receptor
期刊论文
ELIFE, 2021, 卷号: 10, 页码: 24
作者:
Chen, Xiaochen
;
Wang, Lu
;
Cui, Qianqian
;
Ding, Zhanyu
;
Han, Li
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
G-protein-coupled receptor
calcium-sensing receptor
cryo-electron microscopy
calcium ions
nanobody
CaSR
GPCR
cryo-EM
None
Site-directed reduction engineering within bimetal-organic frameworks for efficient size-selective catalysis
期刊论文
MATTER, 2021, 卷号: 4, 期号: 9, 页码: 2919-2935
作者:
Bai, Xiao-Jue
;
Zhai, Xu
;
Zhang, Li-Ying
;
Fu, Yu
;
Qi, Wei
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/11/22
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