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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2021     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers 期刊论文 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9 作者:  Ying, Jieer;  Yang, Lin;  Yin, Jiani C.;  Xia, Guojie;  Xing, Minyan 收藏  |  浏览/下载：29/0  |  提交时间：2021/11/15 biomarkers  tumor  genetic markers  genome instability  Immunotherapy  translational medical research   High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer 期刊论文 BREAST CANCER, 2021 作者:  Zhu, Liang;  Pan, Jia-Ni;  Qian, Ziliang;  Ye, Wei-Wu;  Wang, Xiao-Jia 收藏  |  浏览/下载：23/0  |  提交时间：2021/09/06 CIN  TP53  BRCA1  LPWGS  Breast cancer   Correlation of BRCA1/2 mutations with response to immune checkpoint inhibitors in colorectal cancer. 期刊论文 CANCER RESEARCH, 2021, 卷号: 81 作者:  Jia, Dong-Dong;  Niu, Yanling;  Ma, Tonghui;  Shi, Min 收藏  |  浏览/下载：7/0  |  提交时间：2021/11/01 DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations 期刊论文 EBIOMEDICINE, 2021, 卷号: 69, 页码: 11 作者:   收藏  |  浏览/下载：44/0  |  提交时间：2021/12/01 HER2-negative breast cancer  Germline rare coding mutations  Damage assessment of genomic mutations (DAGM)  Risk assessment  Activity profiles of signalling pathways (APSP)  HER2 signalling pathway  Immune suppression   Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers 期刊论文 INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9 作者:  Li, Meng-Zhu;  Meng, Tao;  Song, Shan-Shan;  Bao, Xu-Bin;  Ma, Lan-Ping 收藏  |  浏览/下载：69/0  |  提交时间：2021/05/24 G-quadruplex stabilizer  MTR-106  BRCA-deficiency  PARP inhibitor  DNA damage   Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文 CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18 作者:  Zhang, Ning;  Tian, Yu-Nan;  Zhou, Li-Na;  Li, Meng-Zhu;  Chen, Hua-Dong 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder 期刊论文 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6 作者:  Liu, Fatao;  Li, Yongsheng;  Ying, Dongjian;  Qiu, Shimei;  He, Yong 收藏  |  浏览/下载：27/0  |  提交时间：2021/04/26 Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells 期刊论文 FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 147, 页码: 10 作者:  Wu, Xiaochen;  Li, Qiqi;  Zhang, Fan;  Wang, Lijun;  Wang, Jun 收藏  |  浏览/下载：38/0  |  提交时间：2021/04/21 PARP inhibitor  BRCA  Pancreatic cancer   Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 31, 页码: 4 作者:  Xiang, Hao-Yue;  Chen, Jian-Yang;  Huan, Xia-Juan;  Chen, Yi;  Gao, Zhao-bing 收藏  |  浏览/下载：14/0  |  提交时间：2021/05/24 Antiproliferative  Cancer  PARP inhibitors  Pyrrolo[12-b]pyridazine   Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文 Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1 作者:  Ning Zhang;  Yu-Nan Tian;  Li-Na Zhou;  Meng-Zhu Li;  Hua-Dong Chen 收藏  |  浏览/下载：18/0  |  提交时间：2021/12/01