QQ客服 官方微博 反馈留言

浏览/检索结果: 共14条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella 期刊论文 RSC MEDICINAL CHEMISTRY, 2021, 页码: 12 作者:  Guan, Xiang-Na;  Zhang, Tao;  Yang, Teng;  Dong, Ze;  Yang, Song 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/16 Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5 作者:  Wang, Leiming;  Li, Xin;  Cui, Hong;  Lei, Xinsheng;  Liu, Hongchun 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/01 Marine nature products  Plocabulin  PM060184  Synthesis  Antiproliferation   Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Wei, Yuan-yuan;  Ma, Yan;  Yao, Song-yu;  Kong, Ling-hui;  Liu, Xiao 收藏  |  浏览/下载：40/0  |  提交时间：2021/11/04 kappa-opioid receptor agonist  4,5-expoxymorphinan  antinociception  conditioned place aversion  sedation  U50,488H  morphine  Nor-BNI  beta-FNA   Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica 期刊论文 JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2111-2120 作者:  Chen, Jian-Jun;  Bai, Wei;  Lu, Yu-Bo;  Feng, Zi-Yun;  Gao, Kun 收藏  |  浏览/下载：32/0  |  提交时间：2021/11/04 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 9 作者:  Wang, Yue;  Guo, Shimeng;  Zhuang, Youwen;  Yun, Ying;  Xu, Peiyu 收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04 Four new diterpenoids from the twigs and leaves of Phyllanthus acidus 期刊论文 TETRAHEDRON, 2021, 卷号: 91, 页码: 6 作者:  Yuan, Yu-Rong;  Li, Yan-Wen;  Huang, Yi-Qi;  Liu, Qun-fang;  Ren, Yu-Hao 收藏  |  浏览/下载：34/0  |  提交时间：2021/08/17 Phyllanthus acidus  Cleistanthane-type diterpenoid  ECD calculation  Biosynthetic pathway  Cytotoxicity   Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12 作者:  Su, Haixia;  Yao, Sheng;  Zhao, Wenfeng;  Zhang, Yumin;  Liu, Jia 收藏  |  浏览/下载：30/0  |  提交时间：2021/08/17 Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17 作者:  Lin, Lin;  Lin, Guangyao;  Zhou, Qingtong;  Bathgate, Ross A. D.;  Gong, Grace Qun 收藏  |  浏览/下载：31/0  |  提交时间：2021/08/17 Synthesis  Structure-activity relationship  Relaxin family peptide receptor 4  Selective agonist  Molecular docking   Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics 期刊论文 ACCOUNTS OF CHEMICAL RESEARCH, 2021, 卷号: 54, 期号: 8, 页码: 1891-1908 作者:  Cai, Lingchao;  Seiple, Ian B.;  Li, Qi 收藏  |  浏览/下载：18/0  |  提交时间：2021/06/11