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浏览/检索结果: 共313条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050202] 项目 项目编号: XDA12050202, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences, 2021- - 收藏  |  浏览/下载：164/0  |  提交时间：2021/05/24 Accucopy: accurate and fast inference of allele-specific copy number alterations from low-coverage low-purity tumor sequencing data 期刊论文 BMC BIOINFORMATICS, 2021, 卷号: 22, 期号: 1, 页码: 18 作者:  Fan, Xinping;  Luo, Guanghao;  Huang, Yu S. 收藏  |  浏览/下载：216/0  |  提交时间：2021/05/24 Cancer genomics  Copy number alterations  Next-generation sequencing   Personalized Medicines-Molecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020229] 项目 项目编号: XDA12020229, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences, 2021- - 收藏  |  浏览/下载：2/0  |  提交时间：2022/01/18 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13 作者:   收藏  |  浏览/下载：45/0  |  提交时间：2022/01/18 GPR84  medium chain fatty acid receptor  GPCR  inflammatory bowel diseases  ulcerative colitis  NLRP3 inflammasome  macrophages   Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1 期刊论文 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14 作者:  Zhang, Chun;  Sun, Yi-Tao;  Gao, Li-Xin;  Feng, Bo;  Yan, Xue 收藏  |  浏览/下载：21/0  |  提交时间：2022/01/18 Advancing COVID-19 diagnosis with privacy-preserving collaboration in artificial intelligence 期刊论文 NATURE MACHINE INTELLIGENCE, 2021, 卷号: 3, 期号: 12, 页码: 1081-1089 作者:  Bai, Xiangd;  Wang, Hanchen;  Ma, Liya;  Xu, Yongchao;  Gan, Jiefeng 收藏  |  浏览/下载：52/0  |  提交时间：2022/01/18 Key-Area Research and Development Program of Guangdong Province[2020B0303070002] 项目 项目编号: 2020B0303070002, 资助机构: Key-Area Research and Development Program of Guangdong Province, 2021- - 收藏  |  浏览/下载：2/0  |  提交时间：2021/12/01 Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages 期刊论文 PHYTOCHEMISTRY, 2021, 卷号: 192, 页码: 10 作者:  Wang, Qiaoqiao;  Zhang, Tian;  Ke, Chang-Qiang;  Tang, Chunping;  Yao, Sheng 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/01 Artemisia codonocephala  Asteraceae  Guaianolides  Anti-inflammation  IL-1 beta  NLRP3