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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2020     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2 期刊论文 DRUG DEVELOPMENT RESEARCH, 2020, 卷号: 81, 期号: 8, 页码: 1004-1018 作者:  Ji, Xiaoyang;  Tan, Wenting;  Zhang, Chunming;  Zhai, Yubo;  Hsueh, Yiching 收藏  |  浏览/下载：46/0  |  提交时间：2021/12/01 coronavirus  cytokine storm  literature mining  renin‐  angiotensin system  topic inference   Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi 收藏  |  浏览/下载：84/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1337-1360 作者:  Yang, Yaxi;  Zhang, Rukang;  Li, Zhaojun;  Mei, Lianghe;  Wan, Shili 收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01 An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells 期刊论文 TOXICOLOGY IN VITRO, 2020, 卷号: 62, 页码: 7 作者:  Wang, Chun-Ming;  Huo, Xiang;  Chen, Jun;  Liu, Jia-Wei;  Yang, Ting-Yu 收藏  |  浏览/下载：16/0  |  提交时间：2022/01/19 Xanthohumol  Reactive oxygen species  Pro-oxidant  Acute lytic cell death  Cell rupture   Licochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 5 作者:  Hu, Chujiao;  Zuo, Yu;  Liu, Jingqiu;  Xu, Heng;  Liao, Weike 收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01 Licochalcone A  Mutant IDH1  Selective inhibitor   The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction 期刊论文 CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542 作者:  Ye, Xiaoqing;  Chen, Gang;  Jin, Jia;  Zhang, Binzhong;  Wang, Yinda 收藏  |  浏览/下载：15/0  |  提交时间：2020/12/24 WDR5  MLL1  histone methyltransferase  small-molecular inhibitor  epigenetics  human acute leukemia