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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
发表日期
2020 [12]
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发表日期:2020
专题:上海药物研究所
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Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 16, 页码: 20
作者:
Lu, Yi-hong
;
Chen, Ming-cang
;
Liu, Fang
;
Xu, Zhou
;
Tian, Xiao-ting
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/24
asiatic acid
modification at C-23
intramolecular hydrogen bonding
cytotoxic activity
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: 5, 页码: 2709-2722
作者:
Nguyen, Phuong D. M.
;
Zheng, Jie
;
Gremminger, Thomas J.
;
Qiu, Liming
;
Zhang, Dong
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency
Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 6, 页码: 12
作者:
Fan, Tianyun
;
Guo, Xixi
;
Zeng, Qingxuan
;
Wei, Wei
;
You, Xuefu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Helicobacter pylori
palmatine
synthesis
structure-activity relationship
urease
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 423-431
作者:
Guo, Wei
;
Yao, Sheng
;
Sun, Pu
;
Yang, Tian-biao
;
Tang, Chun-ping
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
indoleamine 2
3-dioxygenase 1 inhibitor
natural product library
high-throughput fluorescence-based screening
Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 4
作者:
Xiong, Juan
;
Hu, Chang-Ling
;
Wang, Pei-Pei
;
Gao, Ding-Ding
;
Huang, Fang
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Glyptostrobus pensilis
Cupressaceae
Endangered conifer
Spirobiflavonoids
PTP1B inhibition
Bioactivity Prediction Based on Matched Molecular Pair and Matched Molecular Series Methods
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2020, 卷号: 26, 期号: 33, 页码: 4195-4205
作者:
Ding, Xiaoyu
;
Cui, Chen
;
Wang, Dingyan
;
Zhao, Jihui
;
Zheng, Mingyue
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/21
Matched molecular pair
matched molecular series
bioactivity prediction
SAR transfer
application domain
lead optimization
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