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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors 期刊论文 CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+ 作者:  Li, Huiping;  Liu, Rongrui;  Shao, Bin;  Ran, Ran;  Song, Guohong 收藏  |  浏览/下载：22/0  |  提交时间：2020/12/24 Phase I  PARP inhibitor (fluzoparib)  solid tumor  pharmacokinetics  safety  antitumor activity   BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis 期刊论文 THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12 作者:  Li, Guang;  Zheng, Yan-Hua;  Xu, Li;  Feng, Juan;  Tang, Hai-Long 收藏  |  浏览/下载：46/0  |  提交时间：2020/12/24 apoptosis  BRD4 inhibitor  G1 phase cell cycle checkpoint  multiple myeloma   Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422 作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 B cell receptor  Bruton's tyrosine kinase  ibrutinib  small-molecule inhibitor  B cell malignancies   Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter 期刊论文 CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 1, 页码: 12 作者:  Tian, Yu-Nan;  Chen, Hua-Dong;  Tian, Chang-Qing;  Wang, Ying-Qing;  Miao, Ze-Hong 收藏  |  浏览/下载：10/0  |  提交时间：2020/12/24 discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors 期刊论文 actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415 作者:  Lai Mengzhen;  Song Peiran;  Dou Dou;  Diao Yanyan;  Tong Linjiang 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 B cell receptor  Bruton’s tyrosine kinase  ibrutinib  small-molecule inhibitor  B cell malignancies   Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors 期刊论文 AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+ 作者:  Chen, Hua-Dong;  Guo, Ne;  Song, Shan-Shan;  Chen, Chuan-Huizi;  Miao, Ze-Hong 收藏  |  浏览/下载：11/0  |  提交时间：2020/12/24 PARP inhibitors resistance  BRCA2  COX-2  BIRC3  apoptotic resistance   Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors 期刊论文 AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+ 作者:  Chen, Hua-Dong;  Guo, Ne;  Song, Shan-Shan;  Chen, Chuan-Huizi;  Miao, Ze-Hong 收藏  |  浏览/下载：49/0  |  提交时间：2020/12/24 PARP inhibitors resistance  BRCA2  COX-2  BIRC3  apoptotic resistance