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上海药物研究所 [12]
湖南大学 [12]
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期刊论文 [76]
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2019 [76]
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KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules
期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 24, 页码: 5354-5356
作者:
Li, Zhaojun
;
Li, Xutong
;
Liu, Xiaohong
;
Fu, Zunyun
;
Xiong, Zhaoping
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
p38 MAPK is involved in the immune response to pathogenic Vibrio in the clam Meretrix petechialis
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 95, 页码: 456-463
作者:
Zhang, Shujing
;
Yu, Jiajia
;
Wang, Hongxia
;
Liu, Baozhong
;
Yue, Xin
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  |  
浏览/下载:25/0
  |  
提交时间:2020/03/20
p38 MAPK
Vibrio challenge
Immune defence
MITF
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
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  |  
浏览/下载:63/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
PD-L1 expression levels on tumor cells affect their immunosuppressive activity
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407
作者:
Zheng, Yang
;
Fang, You-Chen
;
Li, Jing
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  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
programmed cell death 1
programmed death-ligand 1
co-culture
immunosuppression
signaling pathway
Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 92, 期号: 1, 页码: 224-229
作者:
Liu, Shu-Bo
;
Lu, Long-Feng
;
Lu, Xiao-Bing
;
Li, Shun
;
Zhang, Yong-An
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  |  
浏览/下载:170/0
  |  
提交时间:2019/10/21
FGFR3
Negative regulator
Interferon
TBK1
Zebrafish
Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 卷号: 38, 期号: 1, 页码: 16
作者:
Peng, Xia
;
Hou, Pengcong
;
Chen, Yi
;
Dai, Yang
;
Ji, Yinchun
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  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Kinase inhibitor
FGFR
CSF-1R
Tumor microenvironment
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326
作者:
Wu, Jianhong
;
Jiang, Qinghui
;
Zhu, Hongwen
;
Zhou, Yanting
;
Lu, Dayun
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  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Dimethyl labeling
Kappa-opioid receptor
Kinase-substrate network
p21-activated kinases
Quantitative phosphoproteomics
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:
Wang,Ning
;
Fan,Yanhua
;
Yuan,Chun-Mao
;
Song,Jialei
;
Yao,Yao
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/08/13
Cancer
Leukemia
Chinese medicinal plant
Melia azedarach
Drug screen
ERK1/2 agonists
Differentiation
Apoptosis
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 15
作者:
Jin, Nan
;
Bi, Aiwei
;
Lan, Xiaojing
;
Xu, Jun
;
Wang, Xiaomin
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  |  
浏览/下载:61/0
  |  
提交时间:2020/07/01
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