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科研机构
上海药物研究所 [19]
复旦大学上海医学院 [4]
海洋研究所 [2]
合肥物质科学研究院 [2]
西安交通大学 [1]
江苏大学 [1]
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期刊论文 [39]
会议论文 [1]
学位论文 [1]
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2019 [41]
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Oncogenesi... [1]
环境科学技术 [1]
环境科学技术::环境... [1]
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DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 期号: 1, 页码: 15
作者:
Zhang, Zongwang
;
Wu, Yanwei
;
Wu, Bing
;
Qi, Qing
;
Li, Heng
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Systemic sclerosis
SAHH inhibitor
Fibrosis
Inflammation
Vasculopathy
TGF-beta
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
作者:
Xu, Qi
;
Wu, Ning
;
Li, Xiangqian
;
Guo, Chuanlong
;
Li, Chao
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  |  
浏览/下载:25/0
  |  
提交时间:2020/03/20
Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 21
作者:
Chen, Deheng
;
Lu, Tian
;
Yan, Ziqin
;
Lu, Wenchao
;
Lyu, Xilin
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  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Bromodomain
BET protein
BD2
Selective
Crystal structure
Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity
期刊论文
ONCOIMMUNOLOGY, 2019, 卷号: 8, 期号: 11, 页码: 9
作者:
Zhou, Heng
;
Perez-Lanzon, Maria
;
Humeau, Juliette
;
Wang, Yan
;
Senovilla, Laura
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  |  
浏览/下载:79/0
  |  
提交时间:2019/11/10
Anticancer immunity
immunogenic cell death
checkpoint blockade
tumor clearance
Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1386-1393
作者:
Cui, Xue
;
Guo, Yu-e
;
Fang, Jia-hui
;
Shi, Chang-jie
;
Suo, Na
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  |  
浏览/下载:70/0
  |  
提交时间:2020/07/01
donepezil
aricept
oligodendrocyte
oligodendrocyte progenitor cell
differentiation
myelin sheaths
remyelination
CNS demyelinating disorders
multiple sclerosis
Evaluation of Kinetic Inhibition of Methane Hydrate Formation by a Copolymer of N-Vinylcaprolactam with 1-Vinylimidazole
期刊论文
ENERGY & FUELS, 2019, 卷号: 33, 期号: 10, 页码: 10133-10142
作者:
Long, Zhen
;
Lu, Zhilin
;
Ding, Qihang
;
Zhou, Xuebing
;
Lei, Jiao
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  |  
浏览/下载:24/0
  |  
提交时间:2020/10/29
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 782-801
作者:
Wang, Jubo
;
Li, Tinghan
;
Zhao, Tengteng
;
Wu, Tizhi
;
Liu, Chuang
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  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Wogonin
CDK9
AML
Flavonoid
Antitumor
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785
作者:
Zhu, Kongkai
;
Shao, Jingwei
;
Tao, Hongrui
;
Yan, Xue
;
Luo, Cheng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
PRMT5 inhibitor
Anti-proliferative
Cellular target validation
Design and synthesis
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13
作者:
Tian, Chang-Qing
;
Chen, Lin
;
Chen, Hua-Dong
;
Huan, Xia-Juan
;
Hu, Jian-Ping
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  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
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