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上海药物研究所 [5]
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成都生物研究所 [1]
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期刊论文 [13]
发表日期
2019 [13]
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Chemistry ... [1]
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Discovery of betulinaldehyde as a natural ROR gamma t agonist
期刊论文
FITOTERAPIA, 2019, 卷号: 137, 页码: 8
作者:
Yang, Feng
;
Zhang, Ruihan
;
Ni, Dongxuan
;
Luo, Xiaomin
;
Chen, Shijie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
ROR gamma t
Receptor agonist
Triterpenoids
Alpha screen
Molecular docking
Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3229-3236
作者:
Duan, Zhe
;
Liu, Jingqiu
;
Niu, Liping
;
Wang, Jun
;
Feng, Mingqian
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  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
IDH1 mutation
High-throughput screening
Pan-inhibitor
2-HG
Gliomas
Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy
期刊论文
ACS CENTRAL SCIENCE, 2019, 卷号: 5, 期号: 7, 页码: 1278-1288
作者:
Feng, Chao
;
Huang, Yinong
;
He, Wangxiao
;
Cheng, Xiyao
;
Liu, Huili
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  |  
浏览/下载:72/0
  |  
提交时间:2019/10/14
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
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  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Aryl-phosphorus-containing flame retardants induce oxidative stress, the p53-dependent DNA damage response and mitochondrial impairment in A549 cells
期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 250, 页码: 58-67
作者:
Yuan, Shengwu
;
Han, Yingnan
;
Ma, Mei
;
Rao, Kaifeng
;
Wang, Zijian
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  |  
浏览/下载:19/0
  |  
提交时间:2020/10/21
Phosphorus-containing flame retardants
Reactive oxygen species
Mitochondrial damage
p53 transfection
Gene expression
Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388
作者:
Tao, Hongrui
;
Yan, Xue
;
Zhu, Kongkai
;
Zhang, Hua
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
virtual screening
epigenetic inhibitor
antiproliferation
molecular docking
Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
作者:
Ye, Zhen-Nan
;
Yuan, Feng
;
Liu, Jie-Qing
;
Peng, Xing-Rong
;
An, Tao
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  |  
浏览/下载:59/0
  |  
提交时间:2019/07/29
4 beta HWE
Wnt signaling pathway
beta-catenin
colorectal cancer
Genotoxicity evaluation of carbon monoxide and 1,3-butadiene using a new joint technology: the in vitro gamma H2AX HCS assay combined with air-liquid interface system
期刊论文
TOXICOLOGY MECHANISMS AND METHODS, 2019, 卷号: 29, 期号: 1, 页码: 1-7
作者:
Zhang, Sen
;
Chen, Huan
;
Wang, An
;
Liu, Yong
;
Hou, Hongwei
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  |  
浏览/下载:1/0
  |  
提交时间:2020/07/14
gamma H2AX
genotoxicity
high content screening
carbon monoxide
1,3-butadiene
air-liquid interface system
Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-kappa B activation and cell migration
期刊论文
MEDCHEMCOMM, 2019, 卷号: 10, 期号: 4
作者:
Huang, Ri-Zhen
;
Liang, Gui-Bin
;
Li, Mei-Shan
;
Fang, Yi-Lin
;
Zhao, Shi-Feng
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  |  
浏览/下载:38/0
  |  
提交时间:2019/11/26
Screening of acetylcholinesterase inhibitors and characterizing of phytochemical constituents from Dichocarpum auriculatum (Franch.) W.T. Wang & P. K. Hsiao through UPLC-MS combined with an acetylcholinesterase inhibition assay in vitro
期刊论文
2019, 卷号: 245, 页码: 112185
作者:
Li Pei
;
Liu Shuangshuang
;
Liu Qing
;
Shen Jie
;
Yang Runmei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Acetylcholinesterase
Alkaloids
Dichocarpum auriculatum
Phytochemical analysis
UPLC-MS
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