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上海药物研究所 [8]
山东大学 [5]
西安交通大学 [3]
力学研究所 [2]
安徽大学 [2]
武汉大学 [2]
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期刊论文 [29]
发表日期
2018 [29]
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Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness
期刊论文
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2018, 卷号: 17, 期号: 6, 页码: 1611-1630
作者:
Feng SL(冯世亮)
;
Zhou LW(周吕文)
;
Zhang Y(章燕)
;
Lv SQ(吕守芹)
;
Long M(龙勉)
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/05/30
Chemotaxis
Cytoskeletal remodeling
Mathematical model
Biochemical
Biomechanical
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
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浏览/下载:84/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
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  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Fu, Xu-Hong
;
Zhang, Xiong
;
Yang, Hong
;
Xu, Xiao-Wei
;
Hu, Zong-Long
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Tang, Qing
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Proliferation
Anticancer drug
Phosphatidylinositol 3-kinase inhibitor
Apoptosis
Structure-activity relationship
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 5, 页码: 767-771
作者:
Basnet, Rajesh
;
Gong, Grace Qun
;
Li, Chenyao
;
Wang, Ming-Wei
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
SGK
AKT
PI3K
Cancer
Signalling: Kinase
Inhibitor
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:
Liang, Xiaofei
;
Li, Feng
;
Chen, Cheng
;
Jiang, Zongru
;
Wang, Aoli
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  |  
浏览/下载:14/0
  |  
提交时间:2019/12/10
PI3K delta
Kinase inhibitor
Acute myeloid leukemia
Structure-activity relationship
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650
作者:
Xiao, Wenqin
;
Li, Bo
;
Sun, Xi
;
Yu, Dandan
;
Xie, Yongsheng
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  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
DCZ3301
T-cell leukemia/lymphoma
apoptosis
cell cycle
PI3K/AKT
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Feng, Hong-Xuan
;
Li, Chun-Pu
;
Shu, Shuang-Jie
;
Liu, Hong
;
Zhang, Hai-Yan
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
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