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浏览/检索结果: 共19条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing 期刊论文 CARBOHYDRATE POLYMERS, 2018, 卷号: 201, 页码: 65-74 作者:  Zhou, Lishuang;  Liao, Wenfeng;  Zeng, Hui;  Yao, Yanli;  Chen, Xia 收藏  |  浏览/下载：153/0  |  提交时间：2019/01/08 Lycium barbarum L.  Pectin  A beta(42)  Alzheimer's disease  Amyloid precursor protein processing   Exploring molecular mechanism of allosteric inhibitor to relieve drug resistance of multiple mutations in HIV-1 protease by enhanced conformational sampling 期刊论文 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, 卷号: 86, 期号: 12, 页码: 1294-1305 作者:  Chen, Jianzhong;  Peng, Cheng;  Wang, Jinan;  Zhu, Weiliang 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 allosteric inhibitor  HIV-1 protease  MM-GBSA  normal mode analysis  REMD   Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：88/0  |  提交时间：2019/01/08 Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：87/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   Inhibiting mechanism of small molecule toward the p53-MDM2 interaction: A molecular dynamic exploration 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 4, 页码: 1763-1777 作者:  Chen, Jianzhong;  Wang, Jinan;  Pang, Laixue;  Zhu, Weiliang 收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 hydrophobic contact scanning  MM-GBSA  p53-MDM2 interaction  principal component analysis  solvated interaction energy   Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Tang, Qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Proliferation  Anticancer drug  Phosphatidylinositol 3-kinase inhibitor  Apoptosis  Structure-activity relationship   Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention 期刊论文 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 5, 页码: 767-771 作者:  Basnet, Rajesh;  Gong, Grace Qun;  Li, Chenyao;  Wang, Ming-Wei 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 SGK  AKT  PI3K  Cancer  Signalling: Kinase  Inhibitor   Crystal structure of the Frizzled 4 receptor in a ligand-free state 期刊论文 NATURE, 2018, 卷号: 560, 期号: 7720, 页码: 666-+ 作者:  Yang, Shifan;  Wu, Yiran;  Xu, Ting-Hai;  de Waal, Parker W.;  He, Yuanzheng 收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08 Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction 期刊论文 JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 222, 页码: 99-106 作者:  Wang, Linlin;  Li, Yuanmin;  Deng, Wen;  Dong, Zhihui;  Li, Xue 收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 Ultrafine granular powder  Traditional herbal decoction  Salvia miltiorrhiza Bunge  Myocardial infarction  Cardio-protection   Synthesis and antibacterial activity of C-2 or C-5 modified and D ring rejiggered canthin-6-one analogues 期刊论文 FOOD CHEMISTRY, 2018, 卷号: 253, 页码: 211-220 作者:  Dai, Jiangkun;  Dan, Wenjia;  Li, Nian;  Wang, Ruixue;  Zhang, Yao 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Synthesis  Canthin-6-one analogues  Antibacterial  Structure-activity relationships  Cell membrane  DNA topoisomerases