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浏览/检索结果: 共74条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791 作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 GPR40 agonist  2,3-Dihydrobenzo[b][1,4]dioxine  Insulin secretion  Type 2 diabetes mellitus   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：130/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection 期刊论文 JOURNAL OF PHARMACOLOGICAL SCIENCES, 2018, 卷号: 138, 期号: 4, 页码: 247-256 作者:  Yao, Xingang;  Guo, Songxin;  Wu, Wenyu;  Wang, Jinan;  Wu, Shengen 收藏  |  浏览/下载：102/0  |  提交时间：2019/01/08 RdRp inhibitor  Quinazolinone derivative  DENV2 infection   BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis 期刊论文 CELLULAR & MOLECULAR IMMUNOLOGY, 2018, 卷号: 15, 期号: 12, 页码: 1047-1056 作者:  Zhou, Jinfeng;  Lai, Weiming;  Yang, Wanjie;  Pan, Juping;  Shen, Hu 收藏  |  浏览/下载：161/0  |  提交时间：2019/01/08 Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds 期刊论文 Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1902-1912 作者:  Gong, Grace Qun;  Wang, Ke;  Dai, Xin-Chuan;  Zhou, Yan;  Basnet, Rajesh 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands 期刊论文 CHEMMEDCHEM, 2018, 卷号: 13, 期号: 22, 页码: 2455-2463 作者:  Qian, Hai-Yan;  Wang, Zhi-Long;  Chen, Li-Li;  Pan, You-Lu;  Xie, Xiao-Yu 收藏  |  浏览/下载：90/0  |  提交时间：2019/01/08 cannabinoids  CB1R  CB2R  heteroaryl pyrimidines  heteroaryl triazines  ligands   Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR 期刊论文 SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873 作者:  Li, R.;  Du, Y.;  Shen, J. 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 BTK inhibitors  B-cell malignancies  molecule docking  3D-QSAR  CoMFA  CoMSIA   Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma 期刊论文 ONCOGENESIS, 2018, 卷号: 7 作者:  Chen, Wei;  Zhang, Hao;  Chen, Zhifeng;  Jiang, Hao;  Liao, Liping 收藏  |  浏览/下载：108/0  |  提交时间：2019/01/08 Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK) 期刊论文 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 44, 页码: 16994-17007 作者:  Gu, Xin;  Bridges, Michael D.;  Yan, Yan;  de Waal, Parker W.;  Zhou, X. Edward 收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08 AMP-activated kinase (AMPK)  biophysics  diabetes  metabolic regulation  cancer  ADaM site  DEER