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上海药物研究所 [7]
西安交通大学 [4]
南华大学 [1]
厦门大学 [1]
新疆理化技术研究所 [1]
昆明植物研究所 [1]
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期刊论文 [13]
会议论文 [1]
学位论文 [1]
发表日期
2017 [15]
学科主题
Chemistry,... [1]
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Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464
作者:
Zhou, Shengbin
;
Duan, Yanan
;
Wang, Jiang
;
Zhang, Jin
;
Sun, Haifeng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines
Mitochondrial respiration
AMPK indirect activators
db/db mice
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532
作者:
Chen, Wen-hua
;
Song, Shan-shan
;
Qi, Ming-hui
;
Huan, Xia-juan
;
Wang, Ying-qing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
PARP-1 inhibitor
olaparib
breast cancer
BRCA-deficient tumors
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 19, 页码: 8145-8159
作者:
Ni, Shuaishuai
;
Wei, Hanwen
;
Li, Baoli
;
Chen, Feifei
;
Liu, Yifu
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4904-4916
作者:
Xiamuxi, Hainimu
;
Wang, Zhen
;
Li, Jianfeng
;
Wang, Yu
;
Wu, Chunhui
收藏
  |  
浏览/下载:121/0
  |  
提交时间:2019/01/08
Dopamine
Serotonin
Multireceptor
Atypical antipsychotic
5-HT1A
甲亢性心功能变化中心磷脂对延迟整流钾离子通道亚基KCNQ1,MIRP1和hERG的影响
学位论文
2017, 2015
SAMIULLAH
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  |  
浏览/下载:6/0
  |  
提交时间:2017/06/20
心磷脂
甲亢
Ikr/IKs
cardiolipin
hyperthyrodism
IKr/IKs
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4904-4916
作者:
Xiamuxi, H (Xiamuxi, Hainimu)
;
Wang, Z (Wang, Zhen)
;
Li, JF (Li, Jianfeng)
;
Wang, Y (Wang, Yu)
;
Wu, CH (Wu, Chunhui)
收藏
  |  
浏览/下载:112/0
  |  
提交时间:2017/10/31
Dopamine
Serotonin
Multireceptor
Atypical Antipsychotic
5-ht1a
Increasing Calpain Expression Regulates hERG Mutation L539fs/47 Induced Cardiomyocyte Apoptosis
会议论文
作者:
Ma, Shuting
;
Zhao, Yun
;
Wei, Yuejiao
;
Sun, Chaofeng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/11/26
NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2
期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2017, 卷号: 44, 页码: 1125-1133
作者:
Huo, JianHua
;
Guo, Xueyan
;
Lu, Qun
;
Qiang, Hua
;
Liu, Ping
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/11/26
hERG mutation
NS1643
patch-clamp
long QT syndrome
Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation
期刊论文
INTERNATIONAL JOURNAL OF TOXICOLOGY, 2017, 卷号: 36, 页码: 314-324
作者:
Luo, Ling
;
Hu, Peijing
;
Miao, Changqing
;
Ma, Aiqun
;
Wang, Tingzhong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/11/26
degradation
hERG channel
QTc interval
clenbuterol
arrhythmia
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