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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 发表日期：2017     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Defining the minimum substrate and charge recognition model of gamma-secretase 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424 作者:  Yan, Yan;  Xu, Ting-Hai;  Melcher, Karsten;  Xu, H. Eric 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 Alzheimer's disease  amyloid beta (A beta)  amyloid precursor protein (APP)  C99, gamma-secretase  minimum substrate  Notch protein  recognition model   Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites 期刊论文 JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 38, 页码: 15826-15837 作者:  Yan, Yan;  Xu, Ting-Hai;  Harikumar, Kaleeckal G.;  Miller, Laurence J.;  Melcher, Karsten 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine 期刊论文 CHINESE JOURNAL OF NATURAL MEDICINES, 2017, 卷号: 15, 期号: 9, 页码: 641-652 作者:  Liu Qin;  Wang Shun-Chun;  Ding Kan 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 Alzheimer's disease  Polysaccharides  Traditional Chinese medicine   Amyloid beta: structure, biology and structure-based therapeutic development 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235 作者:  Chen, Guo-fang;  Xu, Ting-hai;  Yan, Yan;  Zhou, Yu-ren;  Jiang, Yi 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery   The effect of blocking Notch signaling by gamma-secretase inhibitor on allergic rhinitis 期刊论文 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2017, 卷号: 98 作者:  Shi, Le;  Ma, Yue;  Zheng, Chunquan;  Zhang, Qingzhao 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05 Allergic rhinitis  Notch signaling  gamma-secretase inhibitor  Th cells   Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae 期刊论文 NEURAL REGENERATION RESEARCH, 2017, 卷号: 12, 期号: 12 作者:  Luo, Wen-wei;  Han, Zhao;  Ren, Dong-dong;  Wang, Xin-wei;  Chi, Fang-lu 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/05 nerve regeneration  Atoh1  DAPT  transdifferentiation  gamma secretase inhibitor  cochlea  sensory epithelium  fetal bovine serum  hair cell  supporting cell  hair cell regeneration  neural regeneration   Antiamyloidogenic Activity of A beta 42-Binding Peptoid in Modulating Amyloid Oligomerization 期刊论文 SMALL, 2017 Zhao, Zijian; Zhu, Ling; Li, Haiyun; Cheng, Peng; Peng, Jiaxi; Yin, Yudan; Yang, Yang; Wang, Chen; Hu, Zhiyuan; Yang, Yanlian 收藏  |  浏览/下载：8/0  |  提交时间：2017/12/04 aggregation,amyloid oligomerization,antiamyloidogenic,inhibitor,peptoids  GAMMA-SECRETASE INHIBITORS  SMALL-MOLECULE INHIBITORS  ALZHEIMERS-DISEASE  BETA-PEPTIDE  FIBRIL FORMATION  PROTEIN AGGREGATION  MOUSE MODEL  MECHANISM  NEUROTOXICITY  CONFORMATION   Initial Substrate Binding of gamma-Secretase: The Role of Substrate Flexibility 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 页码: 1279-1290 作者:  Li, Shu[1];  Zhang, Wan[1];  Han, Wei[1] 收藏  |  浏览/下载：9/0  |  提交时间：2019/04/24 gamma-Secretase  amyloid precursor protein  amyloid-beta peptide  intramembrane protease  substrate recognition  notch signal   amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment 期刊论文 actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205 作者:  Chen Guofang;  Xu Tinghai;  Yan Yan;  Zhou Yuren;  Jiang Yi 收藏  |  浏览/下载：49/0  |  提交时间：2020/07/01 BLOOD-BRAIN-BARRIER  INSULIN-DEGRADING ENZYME  SOLID-STATE NMR  NICOTINIC ACETYLCHOLINE-RECEPTORS  METABOTROPIC GLUTAMATE RECEPTORS  ATOMIC-FORCE MICROSCOPY  GAMMA-SECRETASE COMPLEX  SMOOTH-MUSCLE-CELLS  AMELIORATES MEMORY IMPAIRMENT  ENDOTHELIN-CONVERTING ENZYME  amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery