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Mutation L1196M-induced conformational changes and the drug resistant mechanism of anaplastic lymphoma kinase studied by free energy perturbation and umbrella sampling 期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 卷号: 19, 期号: 44, 页码: 30239-30248
作者:  Chen, Jianzhong;  Wang, Jinan;  Zhu, Weiliang
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08
Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors 期刊论文
FRONTIERS IN CHEMISTRY, 2017, 卷号: 5
作者:  Hu, Xiuqin;  Wang, Disha;  Tong, Yi;  Tong, Linjiang;  Wang, Xia
收藏  |  浏览/下载:60/0  |  提交时间:2019/01/08
Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527
作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang
收藏  |  浏览/下载:55/0  |  提交时间:2019/01/08
A novel glycoprotein d-specific monoclonal antibody neutralizes herpes simplex virus 期刊论文
Antiviral research, 2017, 卷号: 147, 页码: 131-141
作者:  Du, Ruikun;  Wang, Lili;  Xu, Hao;  Wang, Zhiying;  Zhang, Tao
收藏  |  浏览/下载:37/0  |  提交时间:2019/05/08
Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2017, 卷号: 35, 期号: 11, 页码: 1693-1700
作者:  Shi, Huiping;  Lai, Bonan;  Chen, Shizhen;  Zhou, Xin;  Nie, Jing
收藏  |  浏览/下载:64/0  |  提交时间:2018/11/05
Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:  Ren, Zhizhong;  Wang, Zhen;  Zhou, X. Edward;  Shi, Huazhong;  Hong, Yechun
收藏  |  浏览/下载:31/0  |  提交时间:2019/01/08
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 598-611
作者:  Qian, Hai-Yan;  Wang, Zhi-Long;  Xie, Xiao-Yu;  Pan, You-Lu;  Li, Gang-Jian
收藏  |  浏览/下载:24/0  |  提交时间:2019/01/08
Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 16, 页码: 3782-3786
作者:  Cui, Jing;  Peng, Xia;  Gao, Dingding;  Dai, Yang;  Ai, Jing
收藏  |  浏览/下载:16/0  |  提交时间:2019/01/08
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 14, 页码: 6018-6035
作者:  Zhu, Wei;  Chen, Hui;  Wang, Yulan;  Wang, Jiang;  Peng, Xia
收藏  |  浏览/下载:20/0  |  提交时间:2019/01/08
Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy 期刊论文
NANOSCALE, 2017, 卷号: 9, 期号: 27, 页码: 9317-9324
作者:  Li, Yuan;  Li, Wei;  Bao, Weier;  Liu, Bin;  Li, Dan
收藏  |  浏览/下载:20/0  |  提交时间:2017/09/06


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