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合肥物质科学研究院 [10]
上海药物研究所 [3]
中国医学科学院 北京... [3]
昆明植物研究所 [2]
四川大学 [2]
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期刊论文 [32]
发表日期
2017 [32]
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Virtual screening of B-Raf kinase inhibitors: A combination of pharmacophore modelling, molecular docking, 3D-QSAR model and binding free energy calculation studies
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 70, 页码: 186-190
作者:
Zhang, Wen
;
Qiu, Kai-Xiong
;
Yu, Fang
;
Xie, Xiao-Guang
;
Zhang, Shu-Qun
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2017/12/11
B-raf Kinase Inhibitors
Virtual Screening
Pharmacophore
Molecular Docking
3d Qsar
Binding Free Energy Calculation
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:
Wang, Beilei
;
Deng, Yuanxin
;
Chen, Yongfei
;
Yu, Kailin
;
Wang, Aoli
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2018/08/16
Btk
Kinase Inhibitor
Irreversible Inhibitor
Structure-activity Relationship
B-cell Lymphoma
Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d] pyrimidine Derivatives Containing ElectrophilicWarheads
期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 5
作者:
Zhang, Qiumeng
;
Hu, Zonglong
;
Shen, Qianqian
;
Chen, Yi
;
Lu, Wei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
thieno[3,2-d] pyrimidines
antitumor activities
acrylamide warheads
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2018/07/26
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