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新型不可逆BTK激酶抑制剂的发现研究 学位论文
北京: 中国科学院研究生院, 2017
作者:  邓远欣
收藏  |  浏览/下载：37/0  |  提交时间：2018/01/17
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli
收藏  |  浏览/下载：39/0  |  提交时间：2018/08/16
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125
作者:  Liang, Qianmao;  Chen, Yongfei;  Yu, Kailin;  Chen, Cheng;  Zhang, Shouxiang
收藏  |  浏览/下载：37/0  |  提交时间：2018/07/26
嘧啶并吡啶酮骨架作为新型蛋白激酶小分子抑制剂的设计、合成及生物活性研究 学位论文
广州生物院: 中国科学院大学, 2017
作者:  余蕾
收藏  |  浏览/下载：434/0  |  提交时间：2018/12/25
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli
收藏  |  浏览/下载：39/0  |  提交时间：2018/07/04
以激酶BTK为靶标的B细胞恶性肿瘤靶向药物研究 学位论文
2017, 2016
贵甫
收藏  |  浏览/下载：6/0  |  提交时间：2017/06/20
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong
收藏  |  浏览/下载：724/0  |  提交时间：2018/07/04
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxyben zamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chro 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017
Liang, Xiaofei; Lv, Fengchao; Wang, Beilei; Yu, Kailin; Wu, Hong; Qi, Ziping; Jiang, Zongru; Chen, Cheng; Wang, Aoli; Miao, Weili; Wang, Wenchao; Hu, Zhenquan; Liu, Juan; Liu, Xiaochuan; Zhao, Zheng; Wang, Li; Zhang, Shanchuan; Ye, Zi; Wang, Chu; Ren, Tao; Wang, Yinsheng; Liu, Qingsong; Liu, Jing
收藏  |  浏览/下载：4/0  |  提交时间：2017/12/03
Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKC beta and focal adhesion kinase 期刊论文
ELIFE, 2017
Shaheen, Samina; Wan, Zhengpeng; Li, Zongyu; Chau, Alicia; Li, Xinxin; Zhang, Shaosen; Liu, Yang; Yi, Junyang; Zeng, Yingyue; Wang, Jing; Chen, Xiangjun; Xu, Liling; Chen, Wei; Wang, Fei; Lu, Yun; Zheng, Wenjie; Shi, Yan; Sun, Xiaolin; Li, Zhanguo; Xiong, Chunyang; Liu, Wanli
收藏  |  浏览/下载：8/0  |  提交时间：2017/12/03
Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKC beta and focal adhesion kinase 期刊论文
ELIFE, 2017, 卷号: 6, 页码: 1-29
作者:  Shaheen, S;  Wan, ZP;  Li, ZY;  Chau, A;  Li, XX
收藏  |  浏览/下载：32/0  |  提交时间：2018/08/28

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