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浏览/检索结果: 共24条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study 期刊论文 ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2017, 卷号: 409, 期号: 28, 页码: 6559-6565 作者:  Su, Chong;  Sun, Hui;  Yang, Hong;  Yin, Lei;  Zhang, Jiwen 收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08 Ion exchange solid phase extraction  LC-MS/MS  Porcine relaxin  Ultrahigh performance liquid chromatography   A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 1158-1169 作者:  Zhou, Jie;  Cai, Xingguang;  Huang, Xun;  Dai, Yuxuan;  Sun, Lidan 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Glucagon  GLP-1/GCGR agonist  Weight-lowering  Diabetes-protective   Amyloid beta: structure, biology and structure-based therapeutic development 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235 作者:  Chen, Guo-fang;  Xu, Ting-hai;  Yan, Yan;  Zhou, Yu-ren;  Jiang, Yi 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery   Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338 作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 11 beta-HSD1 inhibitor  Hupehenols  Dammarane  SAR   W2476 ameliorates beta-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1024-1037 作者:  Li, Ting;  Lin, Guang-yao;  Zhong, Li;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 diabetes  glucose  TXNIP  beta-cells  W2476  high-throughput screening   Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators 期刊论文 NATURE, 2017, 卷号: 546, 期号: 7657, 页码: 312-+ 作者:  Song, Gaojie;  Yang, Dehua;  Wang, Yuxia;  de Graaf, Chris;  Zhou, Qingtong 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK 期刊论文 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 5 作者:  Huang, Qi;  Wang, Ting;  Yang, Liu;  Wang, He-Yao 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 ginsenoside Rb2  NAFLD  type 2 diabetes  hepatosteatosis  autophagy  AMPK  sirt1   The metabolic ER stress sensor IRE1 alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity 期刊论文 NATURE IMMUNOLOGY, 2017, 卷号: 18, 期号: 5, 页码: 519-529 作者:  Shan, Bo;  Wang, Xiaoxia;  Wu, Ying;  Xu, Chi;  Xia, Zhixiong 收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08 Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717 作者:  Li, He;  Huang, Qi;  Chen, Cheng;  Xu, Bin;  Wang, He-Yao 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression 期刊论文 ENDOCRINE, 2017, 卷号: 56, 期号: 1, 页码: 73-81 作者:  Zhu, Jing-Jie;  Huang, Jun-Shang;  Wang, Ting;  Ji, Jun;  Hou, Ai-Jun 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Sanggenol F  Adipogenesis  Adipokine  PPAR gamma  PTP1B  Type 2 diabetes