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浏览/检索结果: 共130条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 24, 页码: 10231-10244 作者:  Liu, Qiufeng;  Huang, Fubao;  Yuan, Xiaojing;  Wang, Kai;  Zou, Yi 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Miao, Chunxiao;  Lv, Yuanyuan;  Zhang, Wanli;  Chai, Xiaoping;  Feng, Lixing 收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 cancer cachexia  PDTC  C2C12 myotubes  3T3-L1 adipocytes  muscle atrophy  fat lipolysis   Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133 作者:  Jin, Jiyu;  Huang, Suling;  Wang, Lei;  Leng, Ying;  Lu, Wei 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 adipose triglyceride lipase inhibitors  Atglistatin  structure-activity relationship  thiourea   Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride 期刊论文 JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 106, 期号: 12, 页码: 3548-3555 作者:  Gui, Zhiping;  Wu, Xingxing;  Wang, Shuyan;  Cao, Yingji;  Wan, Jun 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 microarray  transdermal drug delivery  skin  permeability  pharmacokinetics  biocompatibility   Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336 作者:   收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Cyclin-dependent kinase  CDK inhibitor  Structure-activity relationship  In vitro and in vivo profiling   Cyclic helix B peptide protects HK-2 cells from oxidative stress by inhibiting ER stress and activating Nrf2 signalling and autophagy 期刊论文 MOLECULAR MEDICINE REPORTS, 2017, 卷号: 16, 期号: 6, 页码: 8055-8061 作者:   收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 cyclic helix B peptide  renal ischemia-reperfusion injury  tubular epithelial cells  oxidative stress  endoplasmic reticulum stress  autophagy   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:   收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition   Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor 期刊论文 STEM CELL REPORTS, 2017, 卷号: 9, 期号: 6, 页码: 1813-1824 作者:   收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Critical Role of Hepatic Cyp450 sin the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Yu, Cunzhi;  Li, Yu;  Liu, Mingxia;  Gao, Man;  Li, Chenggang 收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 (5R)-5-hydroxytriptolide  functional knockout  cytochrome P450  testes  gamma-H2AX  RNA polymerase II  androgen receptor