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浏览/检索结果: 共8条，第1-8条 帮助 限定条件 发表日期：2016     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 124, 页码: 981-991 作者:  Ma, Guang-Hui;  Ye, Yan;  Zhang, Dan;  Xu, Xin;  Si, Pei 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 HFMD  EV71 3C(Pro)  Non-peptidyl inhibitor  Virtual screening   Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance 期刊论文 Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297 作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan 收藏  |  浏览/下载：38/0  |  提交时间：2019/05/09 Alzheimer's disease  N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)  Streptozotocin  Amyloid beta  Pi3k  Autophagy  App/ps1 transgenic mice  Cognitive deficit  Bace1   Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance 期刊论文 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297 作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 Alzheimer's disease  N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)  streptozotocin  amyloid beta  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit   A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function 期刊论文 ONCOTARGET, 2016, 卷号: 7, 期号: 8, 页码: 9389-9404 作者:  Chen, Gang;  Liu, Junhua;  Chen, Wantao;  Xu, Qin;  Xiao, Meng 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 multi-drug resistance  ABCB1  chemotherapy  apoptosis  panax ginseng   Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor 期刊论文 2016, 卷号: 21, 期号: 3, 页码: 277-289 作者:  Wilson, Brice A. P.;  Alam, Muhammad S.;  Guszczynski, Tad;  Jakob, Michal;  Shenoy, Shilpa R. 收藏  |  浏览/下载：7/0  |  提交时间：2020/01/04 high throughput  p38  non-ATP competitive  enzyme kinetics   Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide 期刊论文 DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 卷号: 10, 页码: 2181-2191 作者:  Jiang, Jinfang;  Pang, Xuehai;  Li, Liang;  Dai, Xiaojian;  Diao, Xingxing 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 enzalutamide  N-methyl deuteration  deuterium kinetic isotope effect  pharmacokinetics   smallmoleculelx2343amelioratescognitivedeficitsinadmodelmicebytargetingbothamyloidproductionandclearance 期刊论文 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1281 作者:  Guo Xiaodan;  Sun Guanglong;  Zhou Tingting;  Xu Xin;  Zhu Zhiyuan 收藏  |  浏览/下载：4/0  |  提交时间：2020/07/01 Alzheimer's disease  N-(1  3-benzodioxol-5-yl)-2-5-chloro-2-methoxy(phenylsulfonyl)anilinoacetamide (LX2343)  streptozotocin  amyloid β  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit   Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance 期刊论文 中国药理学报：英文版, 2016, 卷号: 000, 期号: 010, 页码: 1281 作者:  Guo Xiaodan;  Sun Guanglong;  Zhou Tingting;  Xu Xin;  Zhu Zhiyuan 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 Alzheimer's disease  N-(1  3-benzodioxol-5-yl)-2-5-chloro-2-methoxy(phenylsulfonyl)anilinoacetamide (LX2343)  streptozotocin  amyloid β  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit