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浏览/检索结果: 共11条，第1-10条 帮助 限定条件 发表日期：2016    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 124, 页码: 981-991 作者:  Ma, Guang-Hui;  Ye, Yan;  Zhang, Dan;  Xu, Xin;  Si, Pei 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 HFMD  EV71 3C(Pro)  Non-peptidyl inhibitor  Virtual screening   Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 122, 页码: 382-393 作者:  Kondengaden, Shukkoor M.;  Luo, Liu-fei;  Huang, Kenneth;  Zhu, Mengyuan;  Zang, Lanlan 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 Lysine methyltransferase  G9a inhibitor  Leukemia  MALDI-TOF assay   Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 9, 页码: 1847-1855 作者:  Xu, Yuan;  Yue, Liyan;  Wang, Yulan;  Xing, Jin;  Chen, Zhifeng 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay 期刊论文 Scientific Reports, 2016, 卷号: 6 作者:  Li, Yisu;  Guo, Binbin;  Xu, Zhijian;  Li, Bo;  Cai, Tingting 收藏  |  浏览/下载：9/0  |  提交时间：2019/01/08 Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 15, 页码: 3813-3817 作者:  Wu, Yunlong;  Hu, Junchi;  Ding, Hong;  Chen, Limin;  Zhang, Yuanyuan 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 EZH2  Epigenetics  PRC2  Computational drug design  Pharmacophore-based virtual screening   Applying high-performance computing in drug discovery and molecular simulation 期刊论文 NATIONAL SCIENCE REVIEW, 2016, 卷号: 3, 期号: 1, 页码: 49-63 作者:  Liu, Tingting;  Lu, Dong;  Zhang, Hao;  Zheng, Mingyue;  Yang, Huaiyu 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 high-performance computing  computational drug discovery and design  virtual screening  molecular dynamics simulation  protein folding   Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534 作者:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 103, 页码: 118-128 作者:  Liu, Xia;  Xu, Zhijian;  Hou, Chuanwei;  Wang, Meng;  Chen, Xinhuan 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Hepatitis B virus  Viral genomic DNA and cccDNA synthesis  Human ribonucleotide reductase small subunit M2 (RRM2)  Small molecule compounds  Drug synergism and drug resistance   Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays 期刊论文 BIOMED RESEARCH INTERNATIONAL, 2016 作者:  Ye, Fei;  Zhang, Weiyao;  Lu, Wenchao;  Xie, Yiqian;  Jiang, Hao 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 e-Science Platform Construction Accelerates the Development of Rational Drug Design 期刊论文 Bulletin of the Chinese Academy of Sciences, 2016, 卷号: 31, 期号: 6, 页码: 624-638 作者:  Hu Junchi;  Xu Pan;  Chen Yantao;  Liu Tingting;  Lu Dong 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 e-Science  rational drug design  computer-aided drug design