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eNOS/NO途径在单侧输尿管梗阻小鼠肾间质微血管病变中的作用与机制 期刊论文
2015
陈雁; 牛潼; 白海涛; 杨晓晶; 张燕林; 羊钦裕
收藏  |  浏览/下载：4/0  |  提交时间：2016/05/17
GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-beta-Induced Smad3 Phosphorylation 期刊论文
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 卷号: 26, 期号: 8, 页码: 1827-1838
作者:  Ai, Jun;  Nie, Jing;  He, Jiangbo;  Guo, Qin;  Li, Mei
收藏  |  浏览/下载：27/0  |  提交时间：2016/01/19
Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model 期刊论文
Experimental and Therapeutic Medicine, 2015, 卷号: 9, 期号: 3, 页码: 737-743
作者:  Tang, Jin;  Jiang, Xianzhen;  Zhou, Yihong;  Xia, Bing;  Dai, Yingbo*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis 期刊论文
The American Journal of the Medical Sciences, 2015, 卷号: 350, 期号: 3, 页码: 195-203
作者:  Tang, Yiting;  Zhang, Fangfang;  Huang, Ling;  Yuan, Qiongjing;  Qin, Jiao
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes 期刊论文
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2015, 卷号: 7, 期号: 9, 页码: 1553-1563
作者:  Chen, Jihui;  Cui, Wentong;  Zhang, Quanbin;  Jia, Yingli;  Sun, Yi
收藏  |  浏览/下载：31/0  |  提交时间：2015/12/21
The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction (SCI收录) 期刊论文
KIDNEY INTERNATIONAL, 2015, 卷号: 88, 页码: 1323-1335
作者:  Qu, Xinli[1];  Jiang, Mengjie[2];  Sun, Yu Bo Yang[1];  Jiang, Xiaoyun[2];  Fu, Ping[3]
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/25
Effect of SOST gene deletion on the progression of renal interstitial fibrosis in obstructive kidney injury. 期刊论文
Renal Failure, 2015
作者:  Wang, Lu-Fei;  Wu, Hao;  Xu, Yang;  Deng, Meng;  Han, Xiang-Long
收藏  |  浏览/下载：10/0  |  提交时间：2019/02/25
Erythropoietin ameliorates renal interstitial fibrosis via the inhibition of fibrocyte accumulation 期刊论文
MOLECULAR MEDICINE REPORTS, 2015, 卷号: 11, 期号: 5
作者:  Geng, Xu Chang;  Hu, Zhou Pang;  Lian, Guo Yong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Renal fibrosis is not reduced by blocking transforming growth factor-beta signaling in matrix-producing interstitial cells 期刊论文
KIDNEY INTERNATIONAL, 2015, 卷号: 88, 期号: 3
作者:  Neelisetty, Surekha;  Alford, Catherine;  Reynolds, Karen;  Woodbury, Luke;  Nlandu-Khodo, Stellar
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/13

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