Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations

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	Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations
	Lij, Han 1; Su, Guanyong 2,3; Zou, Ming 1; Yu, Liqin 1; Letcher, Robert J.3; Yu, Hongxia 2; Giesy, John P.2,4,5,6,7; Zhou, Bingsheng 8; Liu, Chunsheng 1
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2015-11-03
卷号	49 期号:21 页码:12975-12983
ISSN号	0013-936X
英文摘要	The synthetic flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequently detected in natural waters, and its maximum concentration ever reported is 377 ng/L. However, information on the adverse effects of environmentally relevant concentrations of TDCIPP on aquatic organisms are totally unknown. In this study, <12-h old water fleas, D. magna, were exposed to concentrations of 0, 65 +/- 7.1, 550 +/- 33, or 6500 +/- 1400 ng/L TDCIPP, and dose- and time-dependent effects on reproduction and development were evaluated. Sequences of genes of D. magna were obtained from the National Center for Biotechnology Information and were used to develop PCR arrays for D. magna. Arrays were then used to study transcriptional responses of D. magna to TDCIPP. Exposure to environmentally relevant concentrations of TDCIPP significantly decreased fecundity as well as length of F-0 and F-1 generations. Transcriptional responses showed that, of the 155 genes tested, expressions of 57 genes were significantly changed, and some changes occurred following exposure to environmentally relevant concentrations (i.e., 65 +/- 7.1 and 550 +/- 23 ng/L). Furthermore, pathways related to protein synthesis and metabolism and endocytosis were considered to be significantly affected in a dose- and time-dependent manner and might be responsible for TDCIPP-induced reproductive and developmental toxicities.
WOS标题词	Science & Technology ; Technology ; Life Sciences & Biomedicine
类目[WOS]	Engineering, Environmental ; Environmental Sciences
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
关键词[WOS]	ORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; MASS-SPECTROMETRY METHOD ; ZEBRAFISH DANIO-RERIO ; ENDOCRINE DISRUPTION ; DEVELOPMENTAL EXPOSURE ; CHICKEN EMBRYOS ; SURFACE WATERS ; IN-VITRO ; TDCPP
收录类别	SCI
语种	英语
WOS记录号	WOS:000364355300043
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/27358]
专题	水生生物研究所_水环境工程研究中心_期刊论文
作者单位	1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China 2.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210089, Jiangsu, Peoples R China 3.Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada 4.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada 5.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada 6.Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA 7.Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA 8.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Lij, Han,Su, Guanyong,Zou, Ming,et al. Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(21):12975-12983.
APA	Lij, Han.,Su, Guanyong.,Zou, Ming.,Yu, Liqin.,Letcher, Robert J..,...&Liu, Chunsheng.(2015).Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(21),12975-12983.
MLA	Lij, Han,et al."Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.21(2015):12975-12983.