NMR diffusion and relaxation study on ibuprofen - HSA interaction

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	NMR diffusion and relaxation study on ibuprofen - HSA interaction
	Luo, RS; Liu, ML; Mao, XA
刊名	APPLIED SPECTROSCOPY
	1999-07-01
卷号	53 期号:7 页码:776-779
关键词	NMR diffusion relaxation drug-protein interaction
英文摘要	NMR diffusion and relaxation measurements were applied to study the ibuprofen-protein interaction by changing the drug concentration in solutions containing 0.1 M human serum albumin (HSA). On the basis of the assumption that the drug molecules undergo fast exchange between the binding and free states, the association constant, K-a, for drug-HSA complexes is found to he about 60, and the number of binding sites, n, is about 50. The small association constant and the big binding site number suggest weak interactions between ibuprofen and HAS.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Instruments & Instrumentation ; Spectroscopy
研究领域[WOS]	Instruments & Instrumentation ; Spectroscopy
关键词[WOS]	HUMAN SERUM-ALBUMIN ; NUCLEAR-MAGNETIC-RESONANCE ; PROTEIN-BINDING ; AFFINITY ; DRUGS ; CHROMATOGRAPHY ; PHASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000081808300010
公开日期	2015-12-01
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8375]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Luo, RS,Liu, ML,Mao, XA. NMR diffusion and relaxation study on ibuprofen - HSA interaction[J]. APPLIED SPECTROSCOPY,1999,53(7):776-779.
APA	Luo, RS,Liu, ML,&Mao, XA.(1999).NMR diffusion and relaxation study on ibuprofen - HSA interaction.APPLIED SPECTROSCOPY,53(7),776-779.
MLA	Luo, RS,et al."NMR diffusion and relaxation study on ibuprofen - HSA interaction".APPLIED SPECTROSCOPY 53.7(1999):776-779.