Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning H-1 NMR Spectroscopy and Multivariate Data Analysis

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning H-1 NMR Spectroscopy and Multivariate Data Analysis
	Chen, Wenxue 1,2; Zu, Yukun 3; Huang, Qi 3; Chen, Fener 1; Wang, Guifang 4; Lan, Wenxian 2,5; Bai, Chunxue 4; Lu, Shaohua 6; Yue, Yong ; Deng, Feng 2
刊名	MAGNETIC RESONANCE IN MEDICINE
	2011-12-01
卷号	66 期号:6 页码:1531-1540
关键词	lung cancer HRMAS NMR spectroscopy metabonomics PCA OPLS-DA multivariate data analysis
英文摘要	Lung cancer causes serious health problems. Clinical diagnosis of lung cancer relies on histopathological evalution of tissue specimen. However, extensive knowledge of the metabolic biochemistry of tumors can potentially provide important information for accurate diagnosis of lung cancer. High resolution magic-angle spinning NMR spectroscopy has emerged and be widely acknowledged as an excellent tool in investigating tissue metabolism. Moreover, the combination of high resolution magic-angle spinning NMR technique and multivariate data analysis has become an important metabonomics platform for studying the intact biological tissues. This study reported the metabonomic characteristics of 51 lung tissues from 17 patients with lung cancer using the high resolution magic-angle spinning 1H NMR spectroscopy and the multivariate data analysis methods including principal component analysis and orthogonal partial least squares-discriminant analysis. Clear differences among the metabonomic characteristics of lung cancer tissues at various sites were disclosed. Compared with the adjacent noninvolved tissues, the lung cancer tissues had significantly high levels of aspartate, phosphocholine, glycerophosphocholine and lactate but significantly low levels of glucose and valine. Furthermore, significantly positive (or negative) correlations were observed between the levels of some metabolites such as lactate, fatty acids, valine, phosphocholine, and glycerophosphocholine. Magn Reson Med 66:1531-1540, 2011. ( C) 2011 Wiley Periodicals, Inc.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; NMR-SPECTROSCOPY ; SCREENING TRIAL ; IN-VIVO ; TISSUE ; METABOLISM ; BRAIN ; PROSTATE ; LIVER ; STATISTICS
收录类别	SCI
语种	英语
WOS记录号	WOS:000297285000007
公开日期	2015-12-01
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8232]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Fudan Univ, Dept Chem, Fudan DSM Joint Lab, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol & Phy, Wuhan Inst Phys & Math, Wuhan, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Cardiac Chest Surg, Tongji Hosp, Wuhan 430074, Peoples R China 4.Fudan Univ, Dept Pulm Med, Zhongshan Hosp, Shanghai 200433, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 6.Fudan Univ, Dept Pathol, Zhongshan Hosp, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wenxue,Zu, Yukun,Huang, Qi,et al. Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning H-1 NMR Spectroscopy and Multivariate Data Analysis[J]. MAGNETIC RESONANCE IN MEDICINE,2011,66(6):1531-1540.
APA	Chen, Wenxue.,Zu, Yukun.,Huang, Qi.,Chen, Fener.,Wang, Guifang.,...&Deng, Feng.(2011).Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning H-1 NMR Spectroscopy and Multivariate Data Analysis.MAGNETIC RESONANCE IN MEDICINE,66(6),1531-1540.
MLA	Chen, Wenxue,et al."Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning H-1 NMR Spectroscopy and Multivariate Data Analysis".MAGNETIC RESONANCE IN MEDICINE 66.6(2011):1531-1540.