Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy
	Li, Shuang 1; Huang, Mingming 2; Wang, Xinghua 1,2; Wang, Xuxia ; Chen, Fei 1; Lei, Hao 2; Jiang, Fagang 1
刊名	NEUROCHEMICAL RESEARCH
	2011-12-01
卷号	36 期号:12 页码:2427-2433
关键词	Optic nerve transection Glutamate GABA Magnetic resonance spectroscopy Metabolism
英文摘要	This study aims to investigate the retinal metabolic processes in a rat axotomy model. Retinal metabolic changes in optic nerve transection (ONT) rat model were analyzed by H-1 magnetic resonance spectroscopy (H-1-MRS). Retinal ganglion cells (RGCs) densities were assessed from retinal whole mounts. The retina was stained immunohistochemically with glial fibrillary acidic protein (GFAP). The results showed that the retina in ONT rats had significantly decreased concentrations of gamma-aminobutyric acid (GABA), N-acetylaspartate (NAA), taurine (Tau), creatine (Cr) and increased concentrations of alanine (Ala) compared with control. Examination of glutamate (Glu), glutamine (Gln) and Glx (Glu + Gln) concentrations disclosed no significant differences. The mean density of RGCs reduced from 2,249 +/- A 87 cells/mm(2) in control group to 320 +/- A 56 cells/mm(2) in ONT group. GFAP immunoreactivity was markedly higher in ONT group than that in control group. The retinal metabolism after ONT was associated with neurotransmitter recycling/production perturbation, as well as other metabolic disequilibrium.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]	Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]	TRAUMATIC BRAIN-INJURY ; RESOLUTION H-1-NMR SPECTROSCOPY ; PROTON MR SPECTROSCOPY ; GANGLION-CELLS ; RAT RETINA ; IN-VIVO ; GLUTAMATE RECEPTORS ; N-ACETYLASPARTATE ; VERTEBRATE RETINA ; NEURONAL DEATH
收录类别	SCI
语种	英语
WOS记录号	WOS:000296516500028
公开日期	2015-12-01
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8212]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Li, Shuang,Huang, Mingming,Wang, Xinghua,et al. Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy[J]. NEUROCHEMICAL RESEARCH,2011,36(12):2427-2433.
APA	Li, Shuang.,Huang, Mingming.,Wang, Xinghua.,Wang, Xuxia.,Chen, Fei.,...&Jiang, Fagang.(2011).Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy.NEUROCHEMICAL RESEARCH,36(12),2427-2433.
MLA	Li, Shuang,et al."Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy".NEUROCHEMICAL RESEARCH 36.12(2011):2427-2433.