Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids

	Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids
	Lin, Hailong 2; Zhang, Jing 2; Gao, Peng 1
刊名	journal of clinical laboratory analysis
	2009
卷号	23 期号:1 页码:45-50
关键词	myocardial ischemia metabolomics phospholipids
英文摘要	timely and accurate confirmation of the occurrence of silent myocardial ischemia (smi) is critical both for prevention and therapy management. metabolomics assay may offer an alternative for smi differentiation and altered biomolecule discovery in addition to traditional measures. in this study, plasma samples were obtained from 14 diagnosed smi subjects and 25 healthy controls and analyzed by liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry in view of metabolomics. obtained data were subjected to orthogonal signal correction partial least-squares discriminate analysis. multivariate statistic analysis indicated a clear separation between the two studied groups. plasma concentration fluctuation of four kinds of phospholipids showed tight relationship with the occurrence of smi, among which 1-linoleoylglycerophosphocholine (c18:2) was decreased statistically in smi population (p = 0.01). the plasma phospholipids' changes were before enzymatic alteration in smi, which might be a useful complementary reference to facilitate smi diagnosis. j. clin. lab. anal. 23 : 45-50, 2009. (c) 2009 wiley-liss, inc.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	medical laboratory technology
研究领域[WOS]	medical laboratory technology
关键词[WOS]	coronary-artery disease ; computed-tomography ; endothelial-cells ; cultured human ; heart-disease ; lysophosphatidylcholine ; diagnosis ; metabonomics ; severity
收录类别	SCI
语种	英语
WOS记录号	WOS:000263135500009
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141456]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Municipal Cent Hosp, Div Cardiol, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Lin, Hailong,Zhang, Jing,Gao, Peng. Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids[J]. journal of clinical laboratory analysis,2009,23(1):45-50.
APA	Lin, Hailong,Zhang, Jing,&Gao, Peng.(2009).Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids.journal of clinical laboratory analysis,23(1),45-50.
MLA	Lin, Hailong,et al."Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids".journal of clinical laboratory analysis 23.1(2009):45-50.