Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn

	Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn
	Xu Chen ; Liu Shu ; Liu Zhiqiang ; Song,Rengrui
刊名	高等学校化学学报 chemical journal of chinese universities-chinese
	2014
卷号	35 期号:8 页码:1640-1645
关键词	ALPHA-GLUCOSIDASE INHIBITORS MASS-SPECTROMETRY FREE-RADICALS URIC-ACID EXTRACT DISEASE SERUM ANTIOXIDANTS IONIZATION ALKALOIDS
通讯作者	liu,s
英文摘要	an ultrafiltration uplc/q-tof/ms assay and in vitro xanthine oxidase inhibition assay were combined to screen xanthine oxidase inhibitors in traditional chinese herbal formulae ermiaowan. the result of in vitro xanthine oxidase inhibition assay showed that ermiaowan had a strong xanthine oxidase inhibitory activity, the ic50 value was (0.218 +/- 0.0034) mg/ml. nine compounds were screened and identified as potential xanthine oxidase inhibitors in ermiaowan using ultrafiltration uplc/q-tof/ms. this work provides a certain basis for the development of xanthine oxidase inhibitors and the mechanism clarification of ermiaowan to treat gout and hyperuricemia.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57544]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xu Chen,Liu Shu,Liu Zhiqiang,et al. Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn[J]. 高等学校化学学报 chemical journal of chinese universities-chinese,2014,35(8):1640-1645.
APA	Xu Chen,Liu Shu,Liu Zhiqiang,&Song,Rengrui.(2014).Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn.高等学校化学学报 chemical journal of chinese universities-chinese,35(8),1640-1645.
MLA	Xu Chen,et al."Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn".高等学校化学学报 chemical journal of chinese universities-chinese 35.8(2014):1640-1645.