Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity

	Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity
	Duan, Xiaozheng ; Li, Yunqi ; Zhang, Ran ; Shi,Tongfei ; An,Lijia ; Huang,Qingrong
刊名	european physical journal e
	2014
卷号	37 期号:8 页码:71
关键词	MONTE-CARLO PHOSPHATIDYLINOSITOL 4 PLASMA-MEMBRANE ORDERED MEDIA ELECTROSTATIC INTERACTIONS SURFACE-CHARGE ACIDIC PHOSPHOLIPIDS PROTEIN LOCALIZATION BASIC PEPTIDES BINDING 5-BISPHOSPHATE
通讯作者	duan,xz
英文摘要	monte carlo simulation is employed to investigate the interaction between a polyelectrolyte and a fluid mixed membrane containing neutral (phosphatidyl-choline, pc), monovalent anionic (phosphatidylserine, ps), and multivalent anionic (phosphatidylinositol, pip2) lipids. the effects of the intrinsic polyelectrolyte rigidity and solution ionic strength on the lateral rearrangement and dynamics of different anionic lipid species are systematically studied. our results show that, the increase of polyelectrolyte chain rigidity reduces the loss of polyelectrolyte conformational entropy and the energy gains in electrostatic interaction, but raises the demixing entropy loss of the segregated anionic lipids. therefore, the polyelectrolyte/membrane adsorption strength exhibits a non-monotonic dependence on the polyelectrolyte rigid parameter k(ang), and there exists a certain optimal k(ang) for which the adsorption strength is maximal. because the less loss of chain conformational entropy dominates the increase of the demixing entropy loss of the segregated anionic lipids and the decreases of the electrostatic energy gains, the semiflexible polyelectrolyte adsorbs onto the membrane more firmly than the flexible one. whereas, for the adsorption of rigid polyelectrolyte, larger anionic lipid demixing entropy loss and less energy gain in the electrostatic interaction dominate over the decrease of the polyelectrolyte conformation entropy loss, leading to the desorption of the chain from the membrane. by decreasing the ionic concentration of the salt solution, the certain optimal k(ang) shifts to larger values. the cooperative effects of the adsorbing polyelectrolyte beads determine the concentration gradients and hierarchical mobility of the bound anionic lipids, as well as the polyelectrolyte dynamics.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57496]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Duan, Xiaozheng,Li, Yunqi,Zhang, Ran,et al. Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity[J]. european physical journal e,2014,37(8):71.
APA	Duan, Xiaozheng,Li, Yunqi,Zhang, Ran,Shi,Tongfei,An,Lijia,&Huang,Qingrong.(2014).Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity.european physical journal e,37(8),71.
MLA	Duan, Xiaozheng,et al."Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity".european physical journal e 37.8(2014):71.