pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system

	pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system
	Yu, Shuangjiang ; He, Chaoliang ; Lv, Qiang
刊名	rsc advances
	2014
卷号	4 期号:108 页码:63070-63078
关键词	BLOCK-COPOLYMER MICELLES CANCER-THERAPY POLYMERIC MICELLES GENE DELIVERY RELEASE NANOPARTICLES DESIGN NANOGELS NANOCARRIERS TUMOR
通讯作者	he,cl
英文摘要	nano-vehicles that exhibit enhanced stability in blood circulation while spontaneously releasing therapeutic cargos at pathological sites in response to specific biological triggers are of interest for on-demand drug delivery. in this work, disulfide cross-linked polyurethane micelles (cl-pums) that respond to ph change and an intracellular reducing agent were developed. the micelles were prepared by cross-linking of poly(ethylene glycol)-polyurethane multiblock copolymers containing tertiary amino and cyclic disulfide moieties via a thiol-disulfide exchange reaction. the cl-pums tended to swell or decompose under a weakly acidic environment or in the presence of an intracellular reducing agent, glutathione (gsh), likely owing to the protonation of the tertiary amino groups and cleavage of the disulfide cross-linking bonds. the doxorubicin (dox)-loaded cl-pums suppressed the initial burst release at ph 7.4 without gsh, while they displayed a triggered drug release manner in response to an acidic environment and gsh. it was found that the intracellular dox release of the dox-loaded cl-pums in hepg2 cells was accelerated by an acidic environment or enhanced intracellular gsh concentration. moreover, the time-dependent cytotoxicity against hepg2 and hela cells of the dox-loaded cl-pums was confirmed by an mtt assay. overall, due to the enhanced stability, selective swelling and decomposition properties in response to intracellular micro-environments, the ph-and reduction-sensitive polyurethane crosslinked nano-carriers can serve as a potential system for intracellular drug delivery.
收录类别	SCI
语种	英语
WOS记录号	WOS:000345701500035
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57286]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yu, Shuangjiang,He, Chaoliang,Lv, Qiang. pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system[J]. rsc advances,2014,4(108):63070-63078.
APA	Yu, Shuangjiang,He, Chaoliang,&Lv, Qiang.(2014).pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system.rsc advances,4(108),63070-63078.
MLA	Yu, Shuangjiang,et al."pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system".rsc advances 4.108(2014):63070-63078.