Improving hemocompatibility of polypropylene via surface-initiated atom transfer radical polymerization for covalently coupling BSA

	Improving hemocompatibility of polypropylene via surface-initiated atom transfer radical polymerization for covalently coupling BSA
	Li, Chunming ; Jin, Jing ; Liu, Jingchuan ; Xu,Xiaodong ; Yin,Jinghua
刊名	rsc advances
	2014
卷号	4 期号:47 页码:24842-24851
关键词	BOVINE SERUM-ALBUMIN TERMINATED SI(100) SURFACES POLYETHERSULFONE MEMBRANE GRAFT-COPOLYMERIZATION BLOCK-COPOLYMERS BLOOD-CELLS SI HYBRIDS ATRP PROTEIN IMMOBILIZATION
通讯作者	jin,j
英文摘要	bovine serum albumin (bsa) modified polypropylene (pp) was fabricated via surface-initiated atom transfer radical polymerization (si-atrp) of poly(ethylene glycol) methacrylate (pegma) and glycidyl methacrylate (gma). kinetics study revealed an approximately linear increase in graft density of the functional brushes with polymerization time. attenuated total reflectance fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy confirmed that comonomers and bsa were successfully immobilized onto pp film. the hydrophilicity of pp was improved by modification with pegma and gma. the balance between the inhibition of bsa adsorption by pegma and the covalent immobilization of bsa by gma through the ring-opening reaction of the epoxy group resulted in the moderate fluorescence intensity of fitc-bsa immobilized pp-g-p (pegma-co-gma). the hemolysis test showed that bsa could decrease the hemolysis rate. red blood cell membrane maximal stress can be reduced by the inertness of bsa as well as the repulsion caused by its electrostatic interactions. whole blood cell attachment tests showed that bsa molecules weakened the interaction between blood cells and the pp surface. therefore, the immobilization of bsa on pp film is an effective approach for improving the hemocompatibility of pp.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57271]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li, Chunming,Jin, Jing,Liu, Jingchuan,et al. Improving hemocompatibility of polypropylene via surface-initiated atom transfer radical polymerization for covalently coupling BSA[J]. rsc advances,2014,4(47):24842-24851.
APA	Li, Chunming,Jin, Jing,Liu, Jingchuan,Xu,Xiaodong,&Yin,Jinghua.(2014).Improving hemocompatibility of polypropylene via surface-initiated atom transfer radical polymerization for covalently coupling BSA.rsc advances,4(47),24842-24851.
MLA	Li, Chunming,et al."Improving hemocompatibility of polypropylene via surface-initiated atom transfer radical polymerization for covalently coupling BSA".rsc advances 4.47(2014):24842-24851.