The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)
	Wei, Guohua; Kumar, Vipin; Xue, Jun; Locke, Robert D.; Matta, Khushi L.
刊名	TETRAHEDRON LETTERS
	2009-10-28
卷号	50 期号:43 页码:5920-5922
关键词	F-4-GlcA Hyaluronic acid synthases (HASs) Oligosaccharides Phosphates
中文摘要	The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain. (C) 2009 Elsevier Ltd. All rights reserved.
WOS记录号	WOS:000270421700011
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/21577]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wei, Guohua,Kumar, Vipin,Xue, Jun,et al. The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)[J]. TETRAHEDRON LETTERS,2009,50(43):5920-5922.
APA	Wei, Guohua,Kumar, Vipin,Xue, Jun,Locke, Robert D.,&Matta, Khushi L..(2009).The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs).TETRAHEDRON LETTERS,50(43),5920-5922.
MLA	Wei, Guohua,et al."The first chemical synthesis of F-4-GlcA beta(1 -> 3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)".TETRAHEDRON LETTERS 50.43(2009):5920-5922.