Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia

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	Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia
	Compton, Michael T.1; Chan, Raymond C. K.2; Walker, Elaine F.3; Buckley, Peter F.4
刊名	INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
	2011-05-01
卷号	29 期号:3 页码:245-250
关键词	Minor physical anomalies Psychosis Schizophrenia
ISSN号	0736-5748
通讯作者	Compton, MT (reprint author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Jr Dr SE,Room 333, Atlanta, GA 30303 USA.
产权排序	2
英文摘要	Minor physical anomalies (MPAs) are subtle signs of developmental deviation that are observed at anelevated frequency among patients with schizophrenia. These minor morphological abnormalities of the craniofacial region and limbs arise during fetal development and represent a set of risk markers for schizophrenia. Although MPAs are not specific to schizophrenia, established findings about MPAs vis-a-vis schizophrenia include the replicated findings that MPAs are more prevalent among individuals with schizophrenia than healthy controls, MPAs are more prevalent among individuals with schizophrenia than unaffected relatives, and MPAs are not consistently associated with symptom domains or other risk markers, such as neurological soft signs. Unresolved questions include whether or not MPAs are more prevalent among unaffected relatives than healthy controls, and which specific MPAs are most associated with schizophrenia. This overview presents three promising avenues of further research on MPAs, including: (1) studies relying on traditional summary scores that combine multiple MPAs, which may have a role in prospective risk stratification in conjunction with other risk markers and endophenotypes; (2) research on specific, quantitatively assessed MPAs (especially in specific craniofacial structures) that may inform neurodevelopmental understandings of schizophrenia; and (3) genetic studies aimed at identifying the heritable and nonheritable determinants of specific MPAs, which may increase the field's understanding of the origins of MPAs and the nature of their association with schizophrenia. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
学科主题	Abnormal psychology,Developmental psychology
收录类别	SCI
语种	英语
WOS记录号	WOS:000290135200007
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/12856]
专题	心理研究所_脑与认知科学国家重点实验室
作者单位	1.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30303 USA 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Emory Univ, Grad Sch Arts & Sci, Dept Psychol, Atlanta, GA 30303 USA 4.Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
推荐引用方式 GB/T 7714	Compton, Michael T.,Chan, Raymond C. K.,Walker, Elaine F.,et al. Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2011,29(3):245-250.
APA	Compton, Michael T.,Chan, Raymond C. K.,Walker, Elaine F.,&Buckley, Peter F..(2011).Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,29(3),245-250.
MLA	Compton, Michael T.,et al."Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 29.3(2011):245-250.