A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells

	A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells
	Gao, X; Bian, W; Yang, J; Tang, K; Kitani, H; Atsumi, T; Jing, N
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2001
卷号	284 期号:5 页码:1098-1103
关键词	N-cadherin embryonal carcinoma P19 cells neuronal differentiation Wnt-1
通讯作者	Jing, N (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	N-cadherin is one of the important molecules for cell to cell interaction in the development of the central nervous system (CNS). In this report, we have shown that N-cadherin mRNA and protein were increased rapidly in retinoic acid (RA)-induced neuronal differentiation of embryonic carcinoma P19 cells. To explore possible roles for N-cadherin during this process, N-cadherin-overexpressing P19 cell lines were established. These transfected cells could differentiate into neurofilament-expressing neurons in the absence of RA. RT-PCR revealed that the expression patterns of development-related genes, such as Oct-3/4, nestin, Notch-1, and Mash-1 were similar between the transfected P19 cells and the RA-induced wild-type P19 cells during their neuronal differentiation. On the contrary, the Wnt-1 gene was up-regulated in the N-cadherin-overexpressing P19 cells, but could not be detected in the wild-type P19 cells. These results suggest N-cadherin may play a role in neuronal differentiation of P19 cells, possibly through the Wnt-1 signaling pathway. (C) 2001 Academic Press.
学科主题	Biochemistry & Molecular Biology ; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	GROWTH-FACTOR ; XENOPUS EMBRYOS ; EXPRESSION ; OVEREXPRESSION ; MORPHOGENESIS ; INDUCTION ; LINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000169703100002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2671]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Gao, X,Bian, W,Yang, J,et al. A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,284(5):1098-1103.
APA	Gao, X.,Bian, W.,Yang, J.,Tang, K.,Kitani, H.,...&Jing, N.(2001).A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,284(5),1098-1103.
MLA	Gao, X,et al."A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284.5(2001):1098-1103.