Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2

	Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2
	Chang, TY; Chang, CCY; Lin, S; Yu, CJ; Li, BL; Miyazaki, A
刊名	CURRENT OPINION IN LIPIDOLOGY
	2001
卷号	12 期号:3 页码:289-296
通讯作者	Chang, TY (reprint author), Dartmouth Coll, Sch Med, Dept Biochem, Hanover, NH 03755 USA.,
英文摘要	Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation. in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distribution of ACAT1 and ACAT2 between humans, mice and monkeys is that, in adult human liver (including hepatocytes and bile duct cells), the major enzyme is ACAT1, rather than ACAT2. There is compelling evidence implicating a role for ACAT1 in macrophage foam-cell formation, and for ACAT2 in intestinal cholesterol absorption. However, further studies at the biochemical and cell biological levels are needed in order to clarify the functional roles of ACAT1 and ACAT2 in the VLDL or chylomicron synthesis/assembly process. Curr Opin Lipidol 12:280-296 (C) 2001 Lippincott Williams & Wilkins.
学科主题	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Cardiovascular System & Cardiology
类目[WOS]	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Peripheral Vascular Disease
关键词[WOS]	LOW-DENSITY-LIPOPROTEIN ; ATHEROSCLEROTIC LESIONS ; ESTERIFICATION ENZYMES ; MOLECULAR-CLONING ; O-ACYLTRANSFERASE ; HUMAN MONOCYTES ; ACAT-1 PROTEIN ; HUMAN LIVER ; FOAM CELLS ; COA
收录类别	SCI
语种	英语
WOS记录号	WOS:000169122800008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2622]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chang, TY,Chang, CCY,Lin, S,et al. Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2[J]. CURRENT OPINION IN LIPIDOLOGY,2001,12(3):289-296.
APA	Chang, TY,Chang, CCY,Lin, S,Yu, CJ,Li, BL,&Miyazaki, A.(2001).Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2.CURRENT OPINION IN LIPIDOLOGY,12(3),289-296.
MLA	Chang, TY,et al."Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2".CURRENT OPINION IN LIPIDOLOGY 12.3(2001):289-296.