A vaccine to coxsackievirus prepared by high pressure

	A vaccine to coxsackievirus prepared by high pressure
	Chen, ZM; Tian, SM; Ruan, KC
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2001
卷号	33 期号:1 页码:128-130
关键词	high hydrostatic pressure coxsackievirus group B (CVB) immunogenicity vaccine
通讯作者	,
英文摘要	Effects of high hydrostatic pressure on infectious and immune activity of coxsackievirus group B (CVB) was described. CVB was completely inactivated at 230 MPa pressure and - 16 degreesC. The inactivated viruses remained highly immunogenic and induced CVB-specific serum antibody at a concentration as low as 1:1 500. 67% mice vaccinated with the pressurized viruses survived the challenge of fatal dose of CVB,These results indicated that the pressurized CVB induced immune reactions to protect mice from the viruses, and would be a potential vaccine candidate for human myocarditis.
学科主题	Biochemistry & Molecular Biology ; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	HIGH HYDROSTATIC-PRESSURE ; HIGH IMMUNOGENICITY ; INACTIVATED VIRUS
收录类别	SCI
语种	中文
WOS记录号	WOS:000166598200023
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2589]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, ZM,Tian, SM,Ruan, KC. A vaccine to coxsackievirus prepared by high pressure[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2001,33(1):128-130.
APA	Chen, ZM,Tian, SM,&Ruan, KC.(2001).A vaccine to coxsackievirus prepared by high pressure.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,33(1),128-130.
MLA	Chen, ZM,et al."A vaccine to coxsackievirus prepared by high pressure".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 33.1(2001):128-130.