A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1

	A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1
	Wang, LM; Chen, ZY; Zhang, Q; Zhu, W; Ding, DF; Lu, CL; He, C
刊名	PROTEIN AND PEPTIDE LETTERS
	2003
卷号	10 期号:1 页码:61-72
关键词	glial cell line-derived neurotrophic factor receptor alpha 1 RT-PCR mutation expression PC12-cells surival and differentiation
通讯作者	,zheyu_chen@hotmail.com ; chenghe@online.sh.cn
英文摘要	The GFRalpha1 cDNA was amplified by RT-PCR from fetal rat hippocampus. The soluble recombinant GFRalpha1 and its mutants were obtained from an Escherichia coli expression system. The biological activity of soluble GFRalpha1 and its mutants were evaluated in PC12 cells. The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	GDNF FAMILY LIGANDS ; TYROSINE KINASE ; LIPID RAFTS ; C-RET ; NEURONAL SURVIVAL ; NERVOUS-SYSTEM ; GFR-ALPHA-1 ; ACTIVATION ; EXPRESSION ; NEURTURIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000181186600008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2225]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, LM,Chen, ZY,Zhang, Q,et al. A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1[J]. PROTEIN AND PEPTIDE LETTERS,2003,10(1):61-72.
APA	Wang, LM.,Chen, ZY.,Zhang, Q.,Zhu, W.,Ding, DF.,...&He, C.(2003).A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1.PROTEIN AND PEPTIDE LETTERS,10(1),61-72.
MLA	Wang, LM,et al."A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1".PROTEIN AND PEPTIDE LETTERS 10.1(2003):61-72.