Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

	Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity
	Wang, B; Xiao, Y; Ding, BB; Zhang, N; Yuan, XB; Gui, L; Qian, KX; Duan, SM; Chen, ZJ; Rao, Y
刊名	CANCER CELL
	2003
卷号	4 期号:1 页码:19-29
通讯作者	Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Beijing 200031, Peoples R China.,
英文摘要	Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant Slit2 protein attracted endothelial cells and promoted tube formation in a Robo1- and phosphatidylinositol kinase-dependent manner. Neutralization of Robo1 reduced the microvessel density and the tumor mass of human malignant melanoma A375 cells in vivo. These findings demonstrate the angiogenic function of Slit-Robo signaling, reveal a mechanism in mediating the crosstalk between cancer cells and endothelial cells, and indicate the effectiveness of blocking this signaling pathway in treating cancers.
学科主题	Oncology; Cell Biology
类目[WOS]	Oncology ; Cell Biology
关键词[WOS]	REPULSIVE AXON GUIDANCE ; NEURONAL MIGRATION ; HEPARAN-SULFATE ; LEUKOCYTE CHEMOTAXIS ; VERTEBRATE SLIT ; P-SELECTIN ; PROTEIN ; DROSOPHILA ; ADHESION ; RECEPTORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000184379000005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2218]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, B,Xiao, Y,Ding, BB,et al. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity[J]. CANCER CELL,2003,4(1):19-29.
APA	Wang, B.,Xiao, Y.,Ding, BB.,Zhang, N.,Yuan, XB.,...&Geng, JG.(2003).Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.CANCER CELL,4(1),19-29.
MLA	Wang, B,et al."Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity".CANCER CELL 4.1(2003):19-29.