Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)

	Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)
	Hu, JH; Ma, YH; Jiang, J; Yang, N; Duan, SH; Jiang, ZH; Mei, ZT; Fei, J; Guo, LH
刊名	NEUROREPORT
	2004
卷号	15 期号:1 页码:42259
关键词	cognitive GABAergic system GABA transporter hippocampus over-expressing transgenic mouse
通讯作者	Fei, J (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jfei@sibs.ac.cn ; mhzhang@sunm.shcnc.ac.cn
英文摘要	There is increasing evidence that GABAergic system plays an important role in the neural control of learning and memory processes. GATI over-expressing mice (NA) were generated, in which GATI is under the control of a neuron-specific enolase (NSE) promoter, to investigate effects of GABA transporter on cognitive function. Our results revealed that NA mice displayed cognitive deterioration in associative learning ability and new object recognition retention, compared with the wild-type littermates (WT2). However, the impaired cognitive function of transgenic mice could be rescued after chronic administration of GATI selective inhibitor for 6 days. In addition, there was no change of the expression of NMDA receptors in NA mice. Taken together, we show a potentially important role for GATI in the neural control of cognitive processes, and indicate great potential for GATI as a clinical target of cognitive disorders.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	MORRIS WATER-MAZE ; MEMORY ; RATS ; RECEPTOR ; BACLOFEN ; LACKING ; BRAIN ; TASK
收录类别	SCI
语种	英语
WOS记录号	WOS:000225139800003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2019]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hu, JH,Ma, YH,Jiang, J,et al. Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)[J]. NEUROREPORT,2004,15(1):42259.
APA	Hu, JH.,Ma, YH.,Jiang, J.,Yang, N.,Duan, SH.,...&Guo, LH.(2004).Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).NEUROREPORT,15(1),42259.
MLA	Hu, JH,et al."Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)".NEUROREPORT 15.1(2004):42259.