Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages

	Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages
	Wang, Y; Chang, ZL
刊名	BIOLOGY OF THE CELL
	2005
卷号	97 期号:7 页码:551-556
关键词	heat-shock response interferon-gamma (IFN-gamma) interferon consensus-sequence binding protein (ICSBP) interleukin-18 (IL-18) macrophage
通讯作者	Wang, Y (reprint author), Third Mil Med Univ, SW Hosp, Inst Burn Res, Chongqing 400038, Peoples R China.,yunyunwy@hotmail.com
英文摘要	Background information. The heat-shock response is a self-defence mechanism that protects cells and organisms from a wide range of harmful stresses. Recent studies revealed that it involved the regulation of cytokine expression. Interleukin-18 (IL-18) is an important cytokine in mediating immune response. Results. We studied interferon-gamma (IFN-gamma)-induced IL-18 expression in heat-shock-treated murine peritoneal macrophages. Our results showed that the heat-shock response significantly inhibited the expression of IFN-gamma-induced pro-inflammatory cytokine IL-18. Interferon consensus sequence binding protein (ICSBP) is a transcription factor that binds to the promoter of IL-18 and regulates the transcription of IL-18. Further research on the down-regulation mechanism showed that the DNA-binding activity of ICSBP was greatly reduced by the heat shock response. Conclusions. These results suggest that the inhibitory effect of heat-shock response on IL-18 production in IFN-gamma-stimulated macrophages is related to the suppression of the binding activity of ICSBP.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	SEQUENCE-BINDING-PROTEIN ; IFN-GAMMA ; SIGNALING PATHWAY ; INTERFERON-GAMMA ; IL-18 ; STRESS ; CELLS ; P40
收录类别	SCI
语种	英语
WOS记录号	WOS:000230780300007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1933]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, Y,Chang, ZL. Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages[J]. BIOLOGY OF THE CELL,2005,97(7):551-556.
APA	Wang, Y,&Chang, ZL.(2005).Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages.BIOLOGY OF THE CELL,97(7),551-556.
MLA	Wang, Y,et al."Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages".BIOLOGY OF THE CELL 97.7(2005):551-556.