Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia (Retracted article. See vol. 30, pg. 2798, 2011)

	Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia (Retracted article. See vol. 30, pg. 2798, 2011)
	Zhang, QP; Xiong, J; Jin, YX; Wu, Q; Ju, W; Liu, C; Wang, J; Liu, Y; Hu, CS; Yang, MZ
刊名	ONCOGENE
	2005
卷号	24 期号:4 页码:573-584
关键词	leukemia T cells chemokine receptor apoptosis chemotaxis
通讯作者	Tan, JQ (reprint author), Wuhan Univ, Sch Med, Med Res Ctr,Inst Allergy & Immune Related Dis, Dept Immunol,Lab Allergy & Clin Immunol, Dong Hu Rd 115, Wuhan 430071, Peoples R China.,jinquan_tan@hotmail.com
英文摘要	We investigated CD4(+)CD34(+), CD8(+)CD34(+), CD4(+)CD34(-), and CD8(+)CD34(-) T cells from cord blood and from typical patients with T-cell-lineage acute lymphocytic leukemia and T-cell-lineage chronic lymphocytic leukemia in terms of expression and functions of CXCR5/CXCL13. We found that CXCR5 was selectively frequently expressed on T-cell-lineage acute (chronic) lymphocytic leukemia (T-ALL) CD8(+)CD34(+) T cells, but not on T-ALL CD4(+)CD34(+), CD4(+)CD34(-), and CD8(+)CD34(-) T cells. CXCR5 was rarely expressed on all types of CD34(+) and CD34(-) CB or T-CLL T cells. CXCL13/B cells attracting chemokine 1 induced significant resistance to TNF-alpha-mediated apoptosis in T-ALL CD8(+)CD34(-) T cells, instead of induction of chemotactic and adhesive responsiveness. A proliferation-inducing ligand expression in T-ALL CD8(+)CD34(+) T cells was upregulated by CXCL13/BCA-1 (B-cell attracting chemokine 1). The CXCR5/CXCL13 pair by means of activation of APRIL ( A proliferation-inducinglig and) induced resistance to apoptosis in T-ALL CD8(+)CD34(+) T cells in livin-dependent manner. In this process, cell - cell contact in culture was necessary. Based on our findings, we suggested that there were differential functions of CXCR5/CXCL13 in distinct types of cells. Normal lymphocytes, especially naive B and T cells, utilized CXCR5/CXCL13 for migration, homing, maturation, and cell homeostasis, as well as secondary lymphoid tissue organogenesis. Meanwhile, certain malignant cells took advantages of CXCR5/CXCL13 for infiltration, resistance to apoptosis, and inappropriate proliferation.
学科主题	Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity
类目[WOS]	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
关键词[WOS]	NECROSIS-FACTOR FAMILY ; RECEPTOR 9/TECK INTERACTION ; B-CELL ; CHEMOKINE RECEPTOR ; DENDRITIC CELLS ; LYMPH-NODES ; STRUCTURAL BASIS ; PROTEIN FAMILY ; ML-IAP ; APRIL
收录类别	SCI
语种	英语
WOS记录号	WOS:000226420400005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1908]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, QP,Xiong, J,Jin, YX,et al. Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia (Retracted article. See vol. 30, pg. 2798, 2011)[J]. ONCOGENE,2005,24(4):573-584.
APA	Zhang, QP.,Xiong, J.,Jin, YX.,Wu, Q.,Ju, W.,...&Tan, JQ.(2005).Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia (Retracted article. See vol. 30, pg. 2798, 2011).ONCOGENE,24(4),573-584.
MLA	Zhang, QP,et al."Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia (Retracted article. See vol. 30, pg. 2798, 2011)".ONCOGENE 24.4(2005):573-584.