The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans

	The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans
	Mao, XM; Cao, F; Nie, XY; Liu, HP; Chen, JY
刊名	FEBS LETTERS
	2006
卷号	580 期号:11 页码:2615-2622
关键词	SWII SNF2 Swi/Snf complex hyphal development virulence Candida albicans
通讯作者	Chen, JY (reprint author), Chinese Acad Sci, SIBS, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jychen@sunm.shcnc.ac.cn
英文摘要	The ability of dimorphic transition between yeast and hyphal forms in Candida albicans is one of the vital determinants for its pathogenicity and virulence. We isolated C albicans SWI1 as a suppressor of the invasive growth defect in a Saccharomyces cerevisiae mutant. Expression of C albicans SWI1 in S. cerevisiae partially complemented the growth defect of a swi1 mutant in the utilization of glycerol. Swi1 is in a complex with Snf2 in C. albicans, and both proteins are localized in the nucleus independent of the growth form. Deleting SWI1 or SNF2 in C albicans prevented true hyphal formation and resulted in constitutive pseudohypha-like growth in all media examined. Furthermore, swi1/swi1 mutant was defective in hypha-specitic gene expression and avirulent in a mouse model of systemic infection. These data strongly suggest the conserved Swi/Snf complex in C. albicans is required for hyphal development and pathogenicity. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	SACCHAROMYCES-CEREVISIAE ; TRANSCRIPTION FACTOR ; PROTEIN-KINASE ; PSEUDOHYPHAL DIFFERENTIATION ; FILAMENTOUS GROWTH ; YEAST ; GENE ; MORPHOGENESIS ; ACTIVATION ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000237686400014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1778]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Mao, XM,Cao, F,Nie, XY,et al. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans[J]. FEBS LETTERS,2006,580(11):2615-2622.
APA	Mao, XM,Cao, F,Nie, XY,Liu, HP,&Chen, JY.(2006).The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans.FEBS LETTERS,580(11),2615-2622.
MLA	Mao, XM,et al."The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans".FEBS LETTERS 580.11(2006):2615-2622.