Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance

	Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
	Zhang, X; Bao, L; Guan, JS
刊名	TRENDS IN PHARMACOLOGICAL SCIENCES
	2006
卷号	27 期号:6 页码:324-329
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	Changes in the number of receptors on the cell surface lead to modulations of physiological functions and pharmacological responses of neurons. Recent studies show that delta-opioid peptide (DOP) and mu-opioid peptide (MOP) receptors have distinct subcellular localizations in neurons. In nociceptive small neurons in the dorsal root ganglia, DOP receptors are sorted into neuropeptide-containing secretory vesicles, enabling the stimulus-induced cell surface expression of these receptors. MOP receptors are constitutively expressed on the cell surface. The physical interaction between DOP receptors and MOP receptors seems to be an important mechanism for the modulation of receptor functions. Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or genetically attenuated. Thus, the delivery and trafficking of DOP receptors are crucial processes that modulate opioid analgesia and tolerance.
学科主题	Pharmacology & Pharmacy
类目[WOS]	Pharmacology & Pharmacy
关键词[WOS]	PROTEIN-COUPLED RECEPTORS ; DORSAL-ROOT GANGLION ; VENTROLATERAL PERIAQUEDUCTAL GRAY ; CHRONIC MORPHINE TREATMENT ; RAT SPINAL-CORD ; KNOCK-OUT MICE ; NEUROPATHIC PAIN ; DOWN-REGULATION ; PHYSICAL-DEPENDENCE ; PERIPHERAL AXOTOMY
收录类别	SCI
语种	英语
WOS记录号	WOS:000238793900007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1734]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, X,Bao, L,Guan, JS. Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2006,27(6):324-329.
APA	Zhang, X,Bao, L,&Guan, JS.(2006).Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance.TRENDS IN PHARMACOLOGICAL SCIENCES,27(6),324-329.
MLA	Zhang, X,et al."Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance".TRENDS IN PHARMACOLOGICAL SCIENCES 27.6(2006):324-329.