Differentiation of liver cells from human primordial germ cell-derived progenitors

	Differentiation of liver cells from human primordial germ cell-derived progenitors
	Chen, B; Shi, JJ; Zheng, JK; Chen, Y; Wang, K; Yang, QZ; Chen, XJ; Yang, ZQ; Zhou, XF; Zhu, YM
刊名	DIFFERENTIATION
	2007
卷号	75 期号:5 页码:350-359
关键词	differentiation human primordial germ cell-derived progenitors hepatocyte
通讯作者	Sheng, HZ (reprint author), Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Ctr Dev Biol, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China.,hzsheng2003@yahoo.com
英文摘要	In previous studies, progenitor embryoid body-derived (EBD) cells have been derived from human embryonic germ cells. These cells express lineage markers of three primary germ layers, although their potential to produce true fetal cells of various types has yet to be tested. To this end, we have transplanted EBD cells into the fetal sheep liver. We show that these cells respond appropriately to environmental cues and give rise to hepatocytes and well-structured bile ducts. These results suggest that EBD cells are relatively uncommitted early progenitors capable of effective incorporation and differentiation in vivo. The ability to generate functional liver cells makes EBD cells potentially useful for cell therapy.
学科主题	Cell Biology ; Developmental Biology
类目[WOS]	Cell Biology ; Developmental Biology
关键词[WOS]	EMBRYONIC STEM-CELLS ; IN-VITRO DIFFERENTIATION ; HEPATOCYTE-LIKE CELLS ; CORD BLOOD ; MOUSE-LIVER ; TRANSPLANTATION ; FUSION ; SHEEP ; VIVO ; LINEAGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000246707100002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1564]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, B,Shi, JJ,Zheng, JK,et al. Differentiation of liver cells from human primordial germ cell-derived progenitors[J]. DIFFERENTIATION,2007,75(5):350-359.
APA	Chen, B.,Shi, JJ.,Zheng, JK.,Chen, Y.,Wang, K.,...&Sheng, HZ.(2007).Differentiation of liver cells from human primordial germ cell-derived progenitors.DIFFERENTIATION,75(5),350-359.
MLA	Chen, B,et al."Differentiation of liver cells from human primordial germ cell-derived progenitors".DIFFERENTIATION 75.5(2007):350-359.