Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3

	Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3
	Fan, J; Akabane, H; Zheng, XH; Zhou, XA; Zhang, L; Liu, Q; Zhang, YL; Yang, J; Zhu, GZ
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2007
卷号	363 期号:3 页码:757-761
关键词	Ptchd3 hedgehog signaling patched male germ cell-specific sperm midpiece
通讯作者	Zhu, GZ (reprint author), Marshall Univ, Dept Sci Biol, Huntington, WV 25755 USA.,zhu4@marshall.edu
英文摘要	The Hedgehog (Hh) signaling pathway plays an important role in various biological processes, including pattern formation, cell fate determination, proliferation, and differentiation. Hh function is mediated through its membrane receptor Patched. Herein, we have characterized a novel Patched-domain containing gene Ptchd3 in mouse. Messenger RNA of Ptchd3 was exclusively detected in the testis, and existed in two isoforms Ptchd3a, and Ptchd3b. The expression of these two mRNA isoforms was shown to be developmentally regulated in testes, and specifically found in male germ cells. Further analysis revealed that the Ptchd3 protein was located on the midpiece of mouse, rat and human sperm. Collectively, these results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function. (C) 2007 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	TRANSGENIC MICE ; MOUSE TESTIS ; HEDGEHOG ; PATHWAY ; LOCALIZATION ; EPIDIDYMIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000250359400051
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1536]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Fan, J,Akabane, H,Zheng, XH,et al. Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,363(3):757-761.
APA	Fan, J.,Akabane, H.,Zheng, XH.,Zhou, XA.,Zhang, L.,...&Zhu, GZ.(2007).Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,363(3),757-761.
MLA	Fan, J,et al."Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363.3(2007):757-761.