An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells

	An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells
	Yu, MC; Su, LL; Zou, L; Liu, Y; Wu, N; Kong, L; Zhuang, ZH; Sun, L; Liu, HP; Hu, JH
刊名	NATURE IMMUNOLOGY
	2008
卷号	9 期号:8 页码:898-907
通讯作者	Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn ; gebaoxue@sibs.ac.cn
英文摘要	The inhibitory signaling of natural killer (NK) cells is crucial in the regulation of innate immune responses. Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream' inhibitory signaling. Consequently, the cytotoxicity of NK cells was higher in beta-arrestin 2-deficient mice but was inhibited in beta-arrestin 2-transgenic mice. Moreover, beta-arrestin 2-deficient mice were less susceptible than wild-type mice to mouse cytomegalovirus infection, an effect that was abolished by depletion of NK cells. Our findings identify a previously unknown mechanism by which the inhibitory signaling in NK cells is regulated.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	MURINE CYTOMEGALOVIRUS-INFECTION ; MICROTUBULE-ORGANIZING CENTER ; NK CELLS ; TYROSINE PHOSPHATASES ; DOWN-REGULATION ; IMMUNE SYNAPSE ; BETA-ARRESTINS ; PIVOTAL ROLE ; HLA-C ; RECEPTORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000257780700013
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1416]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yu, MC,Su, LL,Zou, L,et al. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells[J]. NATURE IMMUNOLOGY,2008,9(8):898-907.
APA	Yu, MC.,Su, LL.,Zou, L.,Liu, Y.,Wu, N.,...&Ge, BX.(2008).An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.NATURE IMMUNOLOGY,9(8),898-907.
MLA	Yu, MC,et al."An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells".NATURE IMMUNOLOGY 9.8(2008):898-907.