SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain

	SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain
	Peng, GD; Han, M; Du, YM; Lin, AN; Yu, L; Zhang, YQ; Jing, NH
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2009
卷号	284 期号:44 页码:30138-30147
通讯作者	Zhang, YQ (reprint author), Fudan Univ, Inst Brain Sci, Inst Neurobiol, Shanghai 200032, Peoples R China.,yuqiuzhang@fudan.edu.cn ; njing@sibs.ac.cn
英文摘要	ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter. Taken together, our results provide a potential downstream target of ERK activation-mediated neuropathic pain.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	CHRONIC CONSTRICTION INJURY ; PRIMARY SENSORY NEURONS ; TRANSCRIPTION FACTOR CREB ; PROTEIN-KINASE CASCADE ; DORSAL-HORN NEURONS ; SPINAL-CORD-INJURY ; SCIATIC-NERVE ; MECHANICAL ALLODYNIA ; INFLAMMATORY PAIN ; GROWTH-FACTOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000271090000017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1299]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Peng, GD,Han, M,Du, YM,et al. SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2009,284(44):30138-30147.
APA	Peng, GD.,Han, M.,Du, YM.,Lin, AN.,Yu, L.,...&Jing, NH.(2009).SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain.JOURNAL OF BIOLOGICAL CHEMISTRY,284(44),30138-30147.
MLA	Peng, GD,et al."SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain".JOURNAL OF BIOLOGICAL CHEMISTRY 284.44(2009):30138-30147.